McDonald, Jacob D. and Doyle-Eisele, Melanie and Kracko, Dean and Lund, Amie and Surratt, Jason D. and Hersey, Scott P. and Seinfeld, John H. and Rohr, Annette C. and Knipping, Eladio M. (2012) Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene. Inhalation Toxicology, 24 (11). pp. 689-697. ISSN 0895-8378. doi:10.3109/08958378.2012.712164. https://resolver.caltech.edu/CaltechAUTHORS:20121015-153502319
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Abstract
The biological response to inhalation of secondary organic aerosol (SOA) was determined in rodents exposed to SOA derived from the oxidation of toluene, a precursor emitted from anthropogenic sources. SOA atmospheres were produced to yield 300 µg·m^(−3) of particulate matter (PM) plus accompanying gases. Whole-body exposures were conducted in mice to assess both pulmonary and cardiovascular effects. ApoE^(−/−) mice were exposed for 7 days and measurements of TBARS and gene expression of heme-oxygenase-1 (HO-1), endothelin-1 (ET-1), and matrix metalloproteinase-9 (MMP-9) were made in aorta. Pulmonary inflammatory responses in both species were measured by bronchoalveolar lavage fluid (BALF) cell counts. No pulmonary inflammation was observed. A mild response was observed in mouse aorta for the upregulation of ET-1 and HO-1, with a trend for increased MMP-9 and TBARS, and. Overall, toluene-derived SOA revealed limited biological response compared with previous studies using this exposure protocol with other environmental pollutants.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2012 Informa Healthcare USA, Inc. Received 11 March 2012; revised 10 July 2012; accepted 11 July 2012. This study was supported by the Electric Power Research Institute. | |||||||||
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| Subject Keywords: | Inhalation; aerosol; toluene | |||||||||
| Issue or Number: | 11 | |||||||||
| DOI: | 10.3109/08958378.2012.712164 | |||||||||
| Record Number: | CaltechAUTHORS:20121015-153502319 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20121015-153502319 | |||||||||
| Official Citation: | Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene Jacob D. McDonald, Melanie Doyle-Eisele, Dean Kracko, Amie Lund, Jason D. Surratt, Scott P. Hersey, John H. Seinfeld, Annette C. Rohr, and Eladio M. Knipping Inhalation Toxicology 2012 24:11, 689-697 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 34905 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Aucoeur Ngo | |||||||||
| Deposited On: | 15 Oct 2012 23:51 | |||||||||
| Last Modified: | 09 Nov 2021 23:11 |
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