CaltechAUTHORS
  A Caltech Library Service

Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene

McDonald, Jacob D. and Doyle-Eisele, Melanie and Kracko, Dean and Lund, Amie and Surratt, Jason D. and Hersey, Scott P. and Seinfeld, John H. and Rohr, Annette C. and Knipping, Eladio M. (2012) Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene. Inhalation Toxicology, 24 (11). pp. 689-697. ISSN 0895-8378. https://resolver.caltech.edu/CaltechAUTHORS:20121015-153502319

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20121015-153502319

Abstract

The biological response to inhalation of secondary organic aerosol (SOA) was determined in rodents exposed to SOA derived from the oxidation of toluene, a precursor emitted from anthropogenic sources. SOA atmospheres were produced to yield 300 µg·m^(−3) of particulate matter (PM) plus accompanying gases. Whole-body exposures were conducted in mice to assess both pulmonary and cardiovascular effects. ApoE^(−/−) mice were exposed for 7 days and measurements of TBARS and gene expression of heme-oxygenase-1 (HO-1), endothelin-1 (ET-1), and matrix metalloproteinase-9 (MMP-9) were made in aorta. Pulmonary inflammatory responses in both species were measured by bronchoalveolar lavage fluid (BALF) cell counts. No pulmonary inflammation was observed. A mild response was observed in mouse aorta for the upregulation of ET-1 and HO-1, with a trend for increased MMP-9 and TBARS, and. Overall, toluene-derived SOA revealed limited biological response compared with previous studies using this exposure protocol with other environmental pollutants.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3109/08958378.2012.712164DOIUNSPECIFIED
http://informahealthcare.com/doi/abs/10.3109/08958378.2012.712164PublisherUNSPECIFIED
ORCID:
AuthorORCID
Surratt, Jason D.0000-0002-6833-1450
Seinfeld, John H.0000-0003-1344-4068
Additional Information:© 2012 Informa Healthcare USA, Inc. Received 11 March 2012; revised 10 July 2012; accepted 11 July 2012. This study was supported by the Electric Power Research Institute.
Funders:
Funding AgencyGrant Number
Electric Power Research InstituteUNSPECIFIED
Subject Keywords:Inhalation; aerosol; toluene
Issue or Number:11
Record Number:CaltechAUTHORS:20121015-153502319
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121015-153502319
Official Citation:Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene Jacob D. McDonald, Melanie Doyle-Eisele, Dean Kracko, Amie Lund, Jason D. Surratt, Scott P. Hersey, John H. Seinfeld, Annette C. Rohr, and Eladio M. Knipping Inhalation Toxicology 2012 24:11, 689-697
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:34905
Collection:CaltechAUTHORS
Deposited By: Aucoeur Ngo
Deposited On:15 Oct 2012 23:51
Last Modified:03 Oct 2019 04:23

Repository Staff Only: item control page