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A Genomic Regulatory Network for Development

Davidson, Eric H. and Rast, Jonathan P. and Oliveri, Paola and Ransick, Andrew and Calestani, Cristina and Yuh, Chiou-Hwa and Minokawa, Takuya and Amore, Gabriele and Hinman, Veronica and Arenas-Mena, César and Otim, Ochan and Brown, C. Titus and Livi, Carolina B. and Lee, Pei Yun and Revilla, Roger and Rust, Alistair G. and Pan, Zheng jun and Schilstra, Maria J. and Clarke, Peter J. C. and Arnone, Maria I. and Rowen, Lee and Cameron, R. Andrew and McClay, David R. and Hood, Leroy and Bolouri, Hamid (2002) A Genomic Regulatory Network for Development. Science, 295 (5560). pp. 1669-1678. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20121023-162524596

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Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20121023-162524596

Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1069883DOIArticle
http://www.sciencemag.org/content/295/5560/1669PublisherArticle
ORCID:
AuthorORCID
Otim, Ochan0000-0001-7272-4356
Brown, C. Titus0000-0001-6001-2677
Cameron, R. Andrew0000-0003-3947-6041
Hood, Leroy0000-0001-7158-3678
Additional Information:© 2002 American Association for the Advancement of Science. We are particularly grateful to E. Branscombe, who arranged for the U.S. Department of Energy's Joint Genome Institute to provide many of the BAC sequences included in this work (19); the remainder were obtained at the Institute for Systems Biology, Seattle, WA. We thank E. Rothenberg of Caltech for perspicacious and very helpful comments on the manuscript. The major embryological aspects of this work were supported by grants from NIH (HD-37105 and RR-06591); the computational aspects were supported by a grant from NIH (GM-61005); the comparative aspects were supported by a grant from the NASA/Ames Fundamental Space Biology program (NAG2-1368); the arrayed cDNA and BAC libraries on which the project depended were produced with the support of a grant from NIH (RR-15044); and the work on the brachyury gene was supported by a Human Frontiers grant (RG0290) to R.A.C. Other support was provided by the Lucille P. Markey Charitable Trust, the Stowers Institute for Medical Research, the Beckman Institute of Caltech, and a grant from NSF (IBN99882875) to R.A.C.
Funders:
Funding AgencyGrant Number
NIHGM-61005
NASANAG2-1368
NIHHD-37105
NIHRR-06591
NIHRR-15044
Human Frontier Science ProgramRG0290
Lucille P. Markey Charitable TrustUNSPECIFIED
Stowers Institute for Medical ResearchUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
NSFIBN-99882875
Issue or Number:5560
Record Number:CaltechAUTHORS:20121023-162524596
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121023-162524596
Official Citation:A Genomic Regulatory Network for Development Eric H. Davidson, Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou-Hwa Yuh, Takuya Minokawa, Gabriele Amore, Veronica Hinman, César Arenas-Mena, Ochan Otim, C. Titus Brown, Carolina B. Livi, Pei Yun Lee, Roger Revilla, Alistair G. Rust, Zheng jun Pan, Maria J. Schilstra, Peter J. C. Clarke, Maria I. Arnone, Lee Rowen, R. Andrew Cameron, David R. McClay, Leroy Hood, and Hamid Bolouri Science 1 March 2002: 295 (5560), 1669-1678. [DOI:10.1126/science.1069883]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35057
Collection:CaltechAUTHORS
Deposited By: Aucoeur Ngo
Deposited On:24 Oct 2012 14:39
Last Modified:03 Oct 2019 04:24

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