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Cell type specification during sea urchin development

Cameron, R. Andrew and Davidson, Eric H. (1991) Cell type specification during sea urchin development. Trends in Genetics, 7 (7). pp. 212-218. ISSN 0168-9525. doi:10.1016/0168-9525(91)90367-Y.

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Recent discoveries indicate that cell lineages and fates play a key role in the establishment of spatially restricted gene expression during sea urchin development. Unique sets of founder cells generate five territories of gene expression by means of an invariant pattern of complete cleavage. Cell lineage analysis demonstrates that the second embryonic axis, the oral-aboral axis, is specified with reference to the first cleavage plane. In the undisturbed embryo, clones that contribute to one territory or another begin to appear at the third cleavage, and founder cell segregation to all five territories is completed by the sixth cleavage. Founder cell segregation is a key feature of mechanisms that establish the spatially defined gene activity of sea urchin embryogenesis.

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Cameron, R. Andrew0000-0003-3947-6041
Additional Information:© 1991 Elsevier Publishers Ltd. Available online 9 June 2003. We thank Andrew Ransick tbr reviewing the manuscript. The research from this laboratory was supported by the NSF (grant DCB-8911829 to R.A.C.) and the NIH (grant HD-05753 to E.H.D.).
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Issue or Number:7
Record Number:CaltechAUTHORS:20121025-162445834
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Official Citation:R. Andrew Cameron, Eric H. Davidson, Cell type specification during sea urchin development, Trends in Genetics, Volume 7, Issue 7, July 1991, Pages 212-218, ISSN 0168-9525, 10.1016/0168-9525(91)90367-Y. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35108
Deposited On:26 Oct 2012 14:57
Last Modified:09 Nov 2021 23:12

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