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Minimum information requested in the annotation of biochemical models (MIRIAM)

Le Novère, Nicolas and Finney, Andrew and Hucka, Michael and Bhalla, Upinder S. and Campagne, Fabien and Collado-Vides, Julio and Crampin, Edmund J. and Halstead, Matt and Klipp, Edda and Mendes, Pedro and Nielsen, Poul and Sauro, Herbert and Shapiro, Bruce and Snoep, Jacky L. and Spence, Hugh D. and Wanner, Barry L. (2005) Minimum information requested in the annotation of biochemical models (MIRIAM). Nature Biotechnology, 23 (12). pp. 1509-1515. ISSN 1087-0156. doi:10.1038/nbt1156.

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Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the main causes for incomplete model descriptions. With today's increased interest in detailed biochemical models, it is necessary to define a minimum quality standard for the encoding of those models. We propose a set of rules for curating quantitative models of biological systems. These rules define procedures for encoding and annotating models represented in machine-readable form. We believe their application will enable users to (i) have confidence that curated models are an accurate reflection of their associated reference descriptions, (ii) search collections of curated models with precision, (iii) quickly identify the biological phenomena that a given curated model or model constituent represents and (iv) facilitate model reuse and composition into large subcellular models.

Item Type:Article
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Le Novère, Nicolas0000-0002-6309-7327
Hucka, Michael0000-0001-9105-5960
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Additional Information:© 2005 Nature Publishing Group. Published online 6 December 2005.
Issue or Number:12
Record Number:CaltechAUTHORS:20121026-181128448
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35132
Deposited By: Linda Taddeo
Deposited On:29 Oct 2012 15:21
Last Modified:09 Nov 2021 23:12

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