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KIR-mediated NK education mediates KIR-associated Crohn's disease susceptibility

Lin, Lin and Ma, C. and Aziz, N. and Rajalingam, Raja and Targan, Stephan and McGovern, Dermot and Braun, Jonathan (2012) KIR-mediated NK education mediates KIR-associated Crohn's disease susceptibility. Immunology, 137 (S1). p. 533. ISSN 0019-2805.

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Purpose/Objective: Natural Killer (NK) cells are innate effector lymphocytes in the host response to infections and tumors through a variety of activating and inhibitory receptors. NK cells require education by self-human leukocyte antigen (HLA) class I molecules through Killer cell Immunoglobulin-like receptors (KIRs) to gain proficient responses. Yet, it remains unknown whether and how KIR-mediated NK education contributes to chronic inflammation in humans.

Item Type:Article
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Lin, Lin0000-0001-6860-9566
Additional Information:© 2012 The Author(s). © 2012 Blackwell Publishing Ltd. Article first published online: 12 Sep. 2012.
Issue or Number:S1
Record Number:CaltechAUTHORS:20121030-104805260
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Official Citation:(2012), Poster Sessions. Immunology, 137: 185–772. doi: 10.1111/imm.12002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35175
Deposited By: Tony Diaz
Deposited On:30 Oct 2012 18:46
Last Modified:09 Mar 2020 13:19

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