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High regulatory gene use in sea urchin embryogenesis: Implications for bilaterian development and evolution

Howard-Ashby, Meredith and Materna, Stefan C. and Brown, C. Titus and Tu, Qiang and Oliveri, Paola and Cameron, R. Andrew and Davidson, Eric H. (2006) High regulatory gene use in sea urchin embryogenesis: Implications for bilaterian development and evolution. Developmental Biology, 300 (1). pp. 27-34. ISSN 0012-1606. PMCID PMC1790870. https://resolver.caltech.edu/CaltechAUTHORS:20121031-090413215

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Abstract

A global scan of transcription factor usage in the sea urchin embryo was carried out in the context of the Strongylocentrotus purpuratus genome sequencing project, and results from six individual studies are here considered. Transcript prevalence data were obtained for over 280 regulatory genes encoding sequence-specific transcription factors of every known family, but excluding genes encoding zinc finger proteins. This is a statistically inclusive proxy for the total “regulome” of the sea urchin genome. Close to 80% of the regulome is expressed at significant levels by the late gastrula stage. Most regulatory genes must be used repeatedly for different functions as development progresses. An evolutionary implication is that animal complexity at the stage when the regulome first evolved was far simpler than even the last common bilaterian ancestor, and is thus of deep antiquity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ydbio.2006.10.016DOIArticle
http://www.sciencedirect.com/science/article/pii/S0012160606013091PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790870/PubMed CentralArticle
ORCID:
AuthorORCID
Brown, C. Titus0000-0001-6001-2677
Cameron, R. Andrew0000-0003-3947-6041
Additional Information:© 2006 Elsevier Inc. Received for publication 5 October 2006; revised 13 October 2006; accepted 13 October 2006. Available online 18 October 2006. Research was supported by NIH grant HD37105; DOE grant DE-FG0203ER63584, and NASA/Ames NAG-1587.
Funders:
Funding AgencyGrant Number
NIHHD37105
Department of Energy (DOE)DE-FG0203ER63584
NASANAG-1587
Subject Keywords:Regulome; Transcription factor usage; Indirect development
Issue or Number:1
PubMed Central ID:PMC1790870
Record Number:CaltechAUTHORS:20121031-090413215
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121031-090413215
Official Citation:Meredith Howard-Ashby, Stefan C. Materna, C. Titus Brown, Qiang Tu, Paola Oliveri, R. Andrew Cameron, Eric H. Davidson, High regulatory gene use in sea urchin embryogenesis: Implications for bilaterian development and evolution, Developmental Biology, Volume 300, Issue 1, 1 December 2006, Pages 27-34, ISSN 0012-1606, 10.1016/j.ydbio.2006.10.016. (http://www.sciencedirect.com/science/article/pii/S0012160606013091)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35198
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:31 Oct 2012 16:19
Last Modified:09 Mar 2020 13:18

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