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The Shoot Apical Meristem Regulatory Peptide CLV3 Does Not Activate Innate Immunity

Segonzac, Cécile and Nimchuk, Zachary L. and Beck, Martina and Tarr, Paul T. and Robatzek, Silke and Meyerowitz, Elliot M. and Zipfel, Cyril (2012) The Shoot Apical Meristem Regulatory Peptide CLV3 Does Not Activate Innate Immunity. Plant Cell, 24 (8). pp. 3186-3192. ISSN 1040-4651. PMCID PMC3462624. doi:10.1105/tpc.111.091264. https://resolver.caltech.edu/CaltechAUTHORS:20121108-084216888

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Abstract

The Arabidopsis thaliana leucine-rich repeat receptor kinase FLAGELLIN SENSING2 (FLS2) is required for the recognition of bacterial flagellin in innate immunity. Recently, FLS2 was proposed to act as a multispecific receptor recognizing unrelated exogenous and endogenous peptide ligands, including CLAVATA3 (CLV3), a key regulator of shoot meristem stem cell production. Here, we report experimental evidence demonstrating that FLS2 does not recognize CLV3 and that the shoot apical meristem is immune to bacteria independently of CLV3 perception.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1105/tpc.111.091264 DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462624/PubMed CentralArticle
ORCID:
AuthorORCID
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 2012 by the American Society of Plant Biologists. Received September 2, 2011; revised January 24, 2012; accepted August 1, 2012; published August 24, 2012. This work was funded by the Gatsby Charitable Foundation (C.Z. and S.R.), by UK Biotechnology and Biological Sciences Research Council Grant BB/G024944/1 (ERA-NET Plant Genomics Pathonet) (C.Z.), and by U.S. National Institutes of Health Grant 1R01GM086639 (E.M.M.). We thank Jeffery Dangl and Detlef Weigel for useful discussions. Author Contributions: E.M.M., Z.L.N., C.S., and C.Z. designed the research; M.B., Z.L.N., C.S., and P.T.T. performed research and analyzed data; and E.M.M., Z.L.N., S.R., and C.Z. wrote the article.
Funders:
Funding AgencyGrant Number
Gatsby Charitable FoundationUNSPECIFIED
Biotechnology and Biological Sciences Research Council (BBSRC)BB/G024944/1
NIH1R01GM086639
Issue or Number:8
PubMed Central ID:PMC3462624
DOI:10.1105/tpc.111.091264
Record Number:CaltechAUTHORS:20121108-084216888
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121108-084216888
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35347
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Nov 2012 22:40
Last Modified:09 Nov 2021 23:14

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