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Expression of Sox family genes in early lamprey development

Uy, Benjamin R. and Simões-Costa, Marcos and Sauka-Spengler, Tatjana and Bronner, Marianne E. (2012) Expression of Sox family genes in early lamprey development. International Journal of Developmental Biology, 56 (5). pp. 377-383. ISSN 0214-6282. PMCID PMC4118928. doi:10.1387/ijdb.113416bu. https://resolver.caltech.edu/CaltechAUTHORS:20121115-084947443

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Abstract

Members of the Sox (Sry-related high mobility group box) family of transcription factors play a variety of roles during development of both vertebrates and invertebrates. A marked expansion in gene number occurred during the emergence of vertebrates, apparently via gene duplication events that are thought to have facilitated new functions. By screening a macroarrayed library as well as the lamprey genome, we have isolated genes of the Sox B, D, E and F subfamilies in the basal jawless vertebrate, lamprey. The expression patterns of all identified Sox genes were examined from gastrulation through early organogenesis (embryonic day 4-14), with particular emphasis on the neural crest, a vertebrate innovation. Coupled with phylogenetic analysis of these Sox genes, the results provide insight into gene duplication and divergence in paralog deployment occurring during early vertebrate evolution.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1387/ijdb.113416bu DOIArticle
http://www.ijdb.ehu.es/web/paper.php?doi=113416buPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118928/PubMed CentralArticle
ORCID:
AuthorORCID
Uy, Benjamin R.0000-0003-0438-880X
Simões-Costa, Marcos0000-0003-1452-7068
Sauka-Spengler, Tatjana0000-0001-9289-0263
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2012 UBC Press. Accepted: 13 February 2012. Final, author-corrected PDF published online: 15 June 2012. We thank Natalya Nikitina for her contribution of previously sequenced genes. This work was supported by NIH grant DE017911 to MEB.
Funders:
Funding AgencyGrant Number
NIHDE017911
Subject Keywords:Sox gene, lamprey, cyclostome, neural crest
Issue or Number:5
PubMed Central ID:PMC4118928
DOI:10.1387/ijdb.113416bu
Record Number:CaltechAUTHORS:20121115-084947443
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121115-084947443
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35472
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Nov 2012 17:59
Last Modified:09 Nov 2021 23:15

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