Uy, Benjamin R. and Simões-Costa, Marcos and Sauka-Spengler, Tatjana and Bronner, Marianne E. (2012) Expression of Sox family genes in early lamprey development. International Journal of Developmental Biology, 56 (5). pp. 377-383. ISSN 0214-6282. PMCID PMC4118928. doi:10.1387/ijdb.113416bu. https://resolver.caltech.edu/CaltechAUTHORS:20121115-084947443
![]()
|
PDF
- Published Version
See Usage Policy. 3MB | |
![]()
|
PDF
- Supplemental Material
See Usage Policy. 302kB |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20121115-084947443
Abstract
Members of the Sox (Sry-related high mobility group box) family of transcription factors play a variety of roles during development of both vertebrates and invertebrates. A marked expansion in gene number occurred during the emergence of vertebrates, apparently via gene duplication events that are thought to have facilitated new functions. By screening a macroarrayed library as well as the lamprey genome, we have isolated genes of the Sox B, D, E and F subfamilies in the basal jawless vertebrate, lamprey. The expression patterns of all identified Sox genes were examined from gastrulation through early organogenesis (embryonic day 4-14), with particular emphasis on the neural crest, a vertebrate innovation. Coupled with phylogenetic analysis of these Sox genes, the results provide insight into gene duplication and divergence in paralog deployment occurring during early vertebrate evolution.
Item Type: | Article | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||||
ORCID: |
| ||||||||||||
Additional Information: | © 2012 UBC Press. Accepted: 13 February 2012. Final, author-corrected PDF published online: 15 June 2012. We thank Natalya Nikitina for her contribution of previously sequenced genes. This work was supported by NIH grant DE017911 to MEB. | ||||||||||||
Funders: |
| ||||||||||||
Subject Keywords: | Sox gene, lamprey, cyclostome, neural crest | ||||||||||||
Issue or Number: | 5 | ||||||||||||
PubMed Central ID: | PMC4118928 | ||||||||||||
DOI: | 10.1387/ijdb.113416bu | ||||||||||||
Record Number: | CaltechAUTHORS:20121115-084947443 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20121115-084947443 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 35472 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 20 Nov 2012 17:59 | ||||||||||||
Last Modified: | 09 Nov 2021 23:15 |
Repository Staff Only: item control page