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Divergence of visual channels in the inner retina

Asari, Hiroki and Meister, Markus (2012) Divergence of visual channels in the inner retina. Nature Neuroscience, 15 (11). pp. 1581-1589. ISSN 1097-6256. PMCID PMC3717330. doi:10.1038/nn.3241. https://resolver.caltech.edu/CaltechAUTHORS:20121129-134641275

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Abstract

Bipolar cells form parallel channels that carry visual signals from the outer to the inner retina. Each type of bipolar cell is thought to carry a distinct visual message to select types of amacrine cells and ganglion cells. However, the number of ganglion cell types exceeds that of the bipolar cells providing their input, suggesting that bipolar cell signals diversify on transmission to ganglion cells. We explored in the salamander retina how signals from individual bipolar cells feed into multiple ganglion cells and found that each bipolar cell was able to evoke distinct responses among ganglion cells, differing in kinetics, adaptation and rectification properties. This signal divergence resulted primarily from interactions with amacrine cells that allowed each bipolar cell to send distinct signals to its target ganglion cells. Our findings indicate that individual bipolar cell–ganglion cell connections have distinct transfer functions. This expands the number of visual channels in the inner retina and enhances the computational power and feature selectivity of early visual processing.


Item Type:Article
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http://dx.doi.org/10.1038/nn.3241DOIArticle
http://www.nature.com/neuro/journal/v15/n11/full/nn.3241.htmlPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717330/PubMed CentralArticle
http://rdcu.be/cnLmPublisherFree ReadCube access
ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Additional Information:© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. Received 27 June; accepted 20 September; published online 21 October 2012. We gratefully acknowledge E. Soucy for his extensive help with the experiments, as well as all of the members of the Meister laboratory for many useful discussions. This work was supported by a Postdoctoral Fellowship for Research Abroad from the Japan Society for the Promotion of Science (H.A.) and grants from the US National Institutes of Health (M.M.). Author Contributions: H.A. and M.M. designed the study and wrote the manuscript. H.A. performed the experiments and analysis.
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Funding AgencyGrant Number
Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
NIHUNSPECIFIED
Issue or Number:11
PubMed Central ID:PMC3717330
DOI:10.1038/nn.3241
Record Number:CaltechAUTHORS:20121129-134641275
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121129-134641275
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35732
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:30 Nov 2012 15:54
Last Modified:09 Nov 2021 23:17

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