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A partial sequence of nuclear events in regenerating rat liver

Mayfield, John E. and Bonner, James (1972) A partial sequence of nuclear events in regenerating rat liver. Proceedings of the National Academy of Sciences of the United States of America, 69 (1). pp. 7-10. ISSN 0027-8424.

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When two lobes of the liver of the adult rat are removed, the cells of the remaining lobe are aroused to renewed cell division. We have studied the early events in such regeneration. The first observable response to such partial hepatectomy is the production in the liver nuclei of rapidly-labeled high-molecular-weight RNA of sequences not produced by normal liver. This is followed, with a lag of about 1 hr, by the appearance of increased (above normal) amounts of chromosomal RNA, again of sequences not produced by normal liver. With a lag of another hour, the template activity in support of RNA synthesis of the liver chromatin increases substantially. These events occur before initiation of DNA synthesis in the cells of the regenerating liver.

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Additional Information:Copyright © 1972 by the National Academy of Sciences. Contributed by James Bonner, October 12 1971. We thank our colleagues David Holmes and Stephen Harris for their advice and counsel. Report of work supported in part by the U.S. Public Health Service Training grant GM 86 and U.S. Public Health Service grant 13762.
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Record Number:CaltechAUTHORS:MAYpnas72
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:3575
Deposited By: Tony Diaz
Deposited On:16 Jun 2006
Last Modified:02 Oct 2019 23:04

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