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Alkane Functionalization via Electrophilic Activation

Labinger, Jay A. (2012) Alkane Functionalization via Electrophilic Activation. In: Alkane C-H Activation by Single-Site Metal Catalysis. Catalysis by Metal Complexes. Vol.38. Springer , Dordrecht, Netherlands, pp. 17-71. ISBN 978-90-481-3697-1.

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Electrophilic activation, which may be defined as the substitution of a transition metal center for a proton to generate a new metal–carbon bond, is the basis of a number of promising approaches to selective catalytic functionalization of alkanes. The field was introduced by the groundbreaking chemistry exhibited by aqueous chloroplatinum complexes, reported by Shilov in the early 1970s. Since then the field has expanded greatly, and electrophilic alkane activation has been demonstrated using a wide variety of species. These include ligand-supported platinum complexes; complexes of additional late transition metals, most commonly palladium but also iridium, gold and others; and even post-transition metals such as mercury. That body of work is surveyed here, with particular emphasis on mechanistic understanding, examples of actual functionalization at sp^3-hybridized C–H bonds in alkanes and related compounds, and assessment of the further development that will be needed for practical applications.

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Labinger, Jay A.0000-0002-1942-9232
Additional Information:© 2012 Springer Science+Business Media Dordrecht. I am grateful to the many students and postdocs, and specifically to my Caltech colleague John Bercaw, with whom I have worked on this topic; their names are listed in the references to our work in this chapter. My collaboration and discussion with them have contributed greatly to any understanding and insight I have managed to convey.
Series Name:Catalysis by Metal Complexes
Record Number:CaltechAUTHORS:20121203-085901585
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Official Citation:Labinger, J. (2012). Alkane Functionalization via Electrophilic Activation. Alkane C-H Activation by Single-Site Metal Catalysis. P. J. Pérez, Springer Netherlands. 38: 17-71.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35756
Deposited By: Tony Diaz
Deposited On:07 Feb 2013 22:58
Last Modified:09 Nov 2021 23:17

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