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Changes in functional connectivity support conscious object recognition

Imamoglu, Fatma and Kahnt, Thorsten and Koch, Christof and Haynes, John-Dylan (2012) Changes in functional connectivity support conscious object recognition. NeuroImage, 63 (4). pp. 1909-1917. ISSN 1053-8119. https://resolver.caltech.edu/CaltechAUTHORS:20121203-103832550

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Abstract

What are the brain mechanisms that mediate conscious object recognition? To investigate this question, it is essential to distinguish between brain processes that cause conscious recognition of a stimulus from other correlates of its sensory processing. Previous fMRI studies have identified large-scale brain activity ranging from striate to high-level sensory and prefrontal regions associated with conscious visual perception or recognition. However, the possible role of changes in connectivity during conscious perception between these regions has only rarely been studied. Here, we used fMRI and connectivity analyses, together with 120 custom-generated, two-tone, Mooney images to directly assess whether conscious recognition of an object is accompanied by a dynamical change in the functional coupling between extrastriate cortex and prefrontal areas. We compared recognizing an object versus not recognizing it in 19 naïve subjects using two different response modalities. We find that connectivity between the extrastriate cortex and the dorsolateral prefrontal cortex (DLPFC) increases when objects are consciously recognized. This interaction was independent of the response modality used to report conscious recognition. Furthermore, computing the difference in Granger causality between recognized and not recognized conditions reveals stronger feedforward connectivity than feedback connectivity when subjects recognized the objects. We suggest that frontal and visual brain regions are part of a functional network that supports conscious object recognition by changes in functional connectivity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuroimage.2012.07.056DOIUNSPECIFIED
http://www.sciencedirect.com/science/article/pii/S1053811912007860PublisherUNSPECIFIED
ORCID:
AuthorORCID
Koch, Christof0000-0001-6482-8067
Additional Information:© 2012 Elsevier Inc. Accepted 25 July 2012; available online 2 August 2012. We thank Jakob Heinzle for valuable comments. This work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) Grants HA 5336/1-1, KFO247, and the Mathers Charitable Foundation.
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)HA 5336/1-1
Deutsche Forschungsgemeinschaft (DFG)KFO247
Mathers Charitable FoundationUNSPECIFIED
Subject Keywords:Conscious object recognition; Functional connectivity; Granger causality
Issue or Number:4
Record Number:CaltechAUTHORS:20121203-103832550
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121203-103832550
Official Citation:Fatma Imamoglu, Thorsten Kahnt, Christof Koch, John-Dylan Haynes, Changes in functional connectivity support conscious object recognition, NeuroImage, Volume 63, Issue 4, December 2012, Pages 1909-1917, ISSN 1053-8119, 10.1016/j.neuroimage.2012.07.056.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35764
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:03 Dec 2012 18:55
Last Modified:03 Mar 2020 13:01

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