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Dynamics of Retrieval Strategies for Remote Memories

Goshen, Inbal and Brodsky, Matthew and Prakash, Rohit and Wallace, Jenelle and Gradinaru, Viviana and Ramakrishnan, Charu and Deisseroth, Karl (2011) Dynamics of Retrieval Strategies for Remote Memories. Cell, 147 (3). pp. 678-689. ISSN 0092-8674.

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Prevailing theory suggests that long-term memories are encoded via a two-phase process requiring early involvement of the hippocampus followed by the neocortex. Contextual fear memories in rodents rely on the hippocampus immediately following training but are unaffected by hippocampal lesions or pharmacological inhibition weeks later. With fast optogenetic methods, we examine the real-time contribution of hippocampal CA1 excitatory neurons to remote memory and find that contextual fear memory recall, even weeks after training, can be reversibly abolished by temporally precise optogenetic inhibition of CA1. When this inhibition is extended to match the typical time course of pharmacological inhibition, remote hippocampus dependence converts to hippocampus independence, suggesting that long-term memory retrieval normally depends on the hippocampus but can adaptively shift to alternate structures. Further revealing the plasticity of mechanisms required for memory recall, we confirm the remote-timescale importance of the anterior cingulate cortex (ACC) and implicate CA1 in ACC recruitment for remote recall.

Item Type:Article
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URLURL TypeDescription DOIArticle
Gradinaru, Viviana0000-0001-5868-348X
Additional Information:© 2011 Elsevier Inc. Received: April 4, 2011; Revised: June 30, 2011; Accepted: September 5, 2011; Published online: October 20, 2011. We thank the entire Deisseroth laboratory for their support. K.D. is supported by the Gatsby Charitable Foundation and the Keck, Snyder, Woo, Yu, and McKnight Foundations, as well as by CIRM, NIMH, NINDS, NIDA, and the DARPA REPAIR program. I.G. is supported by the Machiah Foundation and the Weizmann Institute of Science National Postdoctoral Award Program for Advancing Women in Science, R.P. is supported by the NIH, J.W. is supported by the BioX undergraduate summer research program, and V.G. by the Stanford Graduate Fellowship program.
Funding AgencyGrant Number
Gatsby Charitable FoundationUNSPECIFIED
McKnight FoundationUNSPECIFIED
California Institute for Regenerative Medicine (CIRM)UNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
National Institute on Drug AbuseUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Machiah FoundationUNSPECIFIED
Weizmann Institute of ScienceUNSPECIFIED
BioX undergraduate summer research programUNSPECIFIED
Stanford Graduate FellowshipUNSPECIFIED
W. M. Keck FoundationUNSPECIFIED
H. L. Snyder Medical FoundationUNSPECIFIED
Vincent V.C. Woo FoundationUNSPECIFIED
Albert Yu and Mary Bechmann FoundationUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20121206-085452439
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Official Citation:Inbal Goshen, Matthew Brodsky, Rohit Prakash, Jenelle Wallace, Viviana Gradinaru, Charu Ramakrishnan, Karl Deisseroth, Dynamics of Retrieval Strategies for Remote Memories, Cell, Volume 147, Issue 3, 28 October 2011, Pages 678-689, ISSN 0092-8674, 10.1016/j.cell.2011.09.033.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35842
Deposited By: Tony Diaz
Deposited On:18 Dec 2012 16:45
Last Modified:03 Oct 2019 04:32

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