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Inactivation of the Parietal Reach Region Causes Optic Ataxia, Impairing Reaches but Not Saccades

Hwang, Eun Jung and Hauschild, Markus and Wilke, Melanie and Andersen, Richard A. (2012) Inactivation of the Parietal Reach Region Causes Optic Ataxia, Impairing Reaches but Not Saccades. Neuron, 76 (5). pp. 1021-1029. ISSN 0896-6273. PMCID PMC3597097. doi:10.1016/j.neuron.2012.10.030. https://resolver.caltech.edu/CaltechAUTHORS:20121214-105117596

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Abstract

Lesions in human posterior parietal cortex can cause optic ataxia (OA), in which reaches but not saccades to visual objects are impaired, suggesting separate visuomotor pathways for the two effectors. In monkeys, one potentially crucial area for reach control is the parietal reach region (PRR), in which neurons respond preferentially during reach planning as compared to saccade planning. However, direct causal evidence linking the monkey PRR to the deficits observed in OA is missing. We thus inactivated part of the macaque PRR, in the medial wall of the intraparietal sulcus, and produced the hallmarks of OA, misreaching for peripheral targets but unimpaired saccades. Furthermore, reach errors were larger for the targets preferred by the neural population local to the injection site. These results demonstrate that PRR is causally involved in reach-specific visuomotor pathways, and reach goal disruption in PRR can be a neural basis of OA.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2012.10.030DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597097PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2012 Elsevier Inc. Accepted: October 1, 2012. Published: December 5, 2012. This work was supported by NIH grant EY013337, EY005522, and DARPA award N66001-10-C-2009. E.J.H. was supported by NIH Career Development Award K99 NS062894. We thank Dr. Igor Kagan and Dr. James Bonaiuto for the acquisition and processing of MR images, Dr. Bardia Behabadi for scientific discussion, Tessa Yao for editorial assistance, Kelsie Pejsa and Nicole Sammons for animal care, and Viktor Shcherbatyuk for technical assistance.
Funders:
Funding AgencyGrant Number
NIHEY013337
NIHEY005522
Defense Advanced Research Projects Agency (DARPA)N66001-10-C-2009
NIHK99 NS062894
Issue or Number:5
PubMed Central ID:PMC3597097
DOI:10.1016/j.neuron.2012.10.030
Record Number:CaltechAUTHORS:20121214-105117596
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20121214-105117596
Official Citation:Eun Jung Hwang, Markus Hauschild, Melanie Wilke, Richard A. Andersen, Inactivation of the Parietal Reach Region Causes Optic Ataxia, Impairing Reaches but Not Saccades, Neuron, Volume 76, Issue 5, 6 December 2012, Pages 1021-1029, ISSN 0896-6273, 10.1016/j.neuron.2012.10.030.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:35989
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Dec 2012 19:00
Last Modified:09 Nov 2021 23:19

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