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Dynamics of mitochondria and mitochondrial DNA

Chan, David and Ngo, Huu B. and Chen, Hsiuchen (2012) Dynamics of mitochondria and mitochondrial DNA. FASEB Journal, 26 . Art. No. 103.2. ISSN 0892-6638.

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Mitochondria are dynamic organelles that fuse and divide. The study of mice lacking these dynamic processes has revealed physiological roles for mitochondrial dynamics. Recent studies indicate a link between mitochondrial dynamics and mitochondrial DNA (mtDNA) stability. To study this issue, we have performed structural studies on Tfam, a DNA binding protein that plays a central role in expression, maintenance, and organization of the mitochondrial genome. It activates transcription from mitochondrial promoters and organizes the mitochondrial genome into nucleoids. Using X-ray crystallography, we show that human Tfam forces promoter DNA to undergo a U-turn, reversing the direction of the DNA helix. The structural principles underlying DNA bending converge with those of the unrelated HU family proteins, which play analogous architectural roles in organizing bacterial nucleoids.

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Chan, David0000-0002-0191-2154
Additional Information:© 2012 FASEB.
Record Number:CaltechAUTHORS:20121220-105846739
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:36074
Deposited By: Tony Diaz
Deposited On:20 Dec 2012 22:57
Last Modified:24 Feb 2020 10:30

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