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Wide and scalable field-of-view Talbot-grid-based fluorescence microscopy

Pang, Shuo and Han, Chao and Kato, Mihoko and Sternberg, Paul W. and Yang, Changhuei (2012) Wide and scalable field-of-view Talbot-grid-based fluorescence microscopy. Optics Letters, 37 (23). pp. 5018-5020. ISSN 0146-9592. PMCID PMC3718313.

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Here we report a low-cost and simple wide field-of-view (FOV) on-chip fluorescence-imaging platform, termed fluorescence Talbot microscopy (FTM), which utilizes the Talbot self-imaging effect to enable efficient fluorescence imaging over a large and directly scalable FOV. The FTM prototype has a resolution of 1.2 μm and an FOV of 3.9  mm×3.5  mm. We demonstrate the imaging capability of FTM on fluorescently labeled breast cancer cells (SK-BR-3) and human embryonic kidney 293 (HEK) cells expressing green fluorescent protein.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Kato, Mihoko0000-0003-3827-8879
Sternberg, Paul W.0000-0002-7699-0173
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2012 Optical Society of America. Received September 18, 2012; revised October 24, 2012; accepted November 5, 2012. We thank Danielle V. Bower (Biological Imaging Center, Caltech) for the help in sample preparation. This project is funded by NIH under the grant 1R01AI096226-01.
Funding AgencyGrant Number
Issue or Number:23
Classification Code:OCIS codes: 180.2520, 110.6760
PubMed Central ID:PMC3718313
Record Number:CaltechAUTHORS:20130107-153250959
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Official Citation:S. Pang, C. Han, M. Kato, P. Sternberg, and C. Yang, "Wide and scalable field-of-view Talbot-grid-based fluorescence microscopy," Opt. Lett. 37, 5018-5020 (2012).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:36213
Deposited By: Jason Perez
Deposited On:07 Jan 2013 23:59
Last Modified:21 Apr 2020 17:52

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