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Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity

Hwang, Jae Youn and Lubow, David J. and Chu, David and Sims, Jessica and Alonso-Valenteen, Felix and Gray, Harry B. and Gross, Zeev and Farkas, Daniel L. and Medina-Kauwe, Lali K. (2012) Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity. Journal of Controlled Release, 163 (3). pp. 368-373. ISSN 0168-3659. PMCID PMC3498762. http://resolver.caltech.edu/CaltechAUTHORS:20130110-154703589

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Abstract

The tumor-targeted corrole particle, HerGa, displays preferential toxicity to tumors in vivo and can be tracked via fluorescence for simultaneous detection, imaging, and treatment. We have recently uncovered an additional feature of HerGa in that its cytotoxicity is enhanced by light irradiation. In the present study, we have elucidated the cellular mechanisms for HerGa photoexcitation-mediated cell damage using fluorescence optical imaging. In particular, we found that light irradiation of HerGa produces singlet oxygen, causing mitochondrial damage and cytochrome c release, thus promoting apoptotic cell death. An understanding of the mechanisms of cell death induced by HerGa, particularly under conditions of light-mediated excitation, may direct future efforts in further customizing this nanoparticle for additional therapeutic applications and enhanced potency.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jconrel.2012.09.015DOIArticle
http://www.sciencedirect.com/science/article/pii/S0168365912007031PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498762PubMed CentralArticle
Additional Information:© 2012 Elsevier B.V. Received 6 September 2012, Accepted 22 September 2012, Available online 4 October 2012. This work was supported by grants from the NIH (R01 CA140995, and R01 CA129822). Work at Caltech was supported by NIH DK019038 and the Arnold and Mabel Beckman Foundation. Work at the Technion was supported by The Herbert Irving Cancer and Atherosclerosis Research Fund and The United States–Israel Binational Science Foundation.
Funders:
Funding AgencyGrant Number
NIHR01 CA140995
NIHR01 CA129822
NIHDK019038
Arnold and Mabel Beckman FoundationUNSPECIFIED
Herbert Irving Cancer and Atherosclerosis Research FundUNSPECIFIED
Binational Science Foundation (USA-Israel)UNSPECIFIED
Subject Keywords:Nanoparticles, Drug delivery, A sulfonated gallium(III) corrole, Tumor targeting, Photoexcitation, Singlet oxygen
PubMed Central ID:PMC3498762
Record Number:CaltechAUTHORS:20130110-154703589
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130110-154703589
Official Citation:Jae Youn Hwang, David J. Lubow, David Chu, Jessica Sims, Felix Alonso-Valenteen, Harry B. Gray, Zeev Gross, Daniel L. Farkas, Lali K. Medina-Kauwe, Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity, Journal of Controlled Release, Volume 163, Issue 3, 10 November 2012, Pages 368-373, ISSN 0168-3659, 10.1016/j.jconrel.2012.09.015.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:36307
Collection:CaltechAUTHORS
Deposited By: John Wade
Deposited On:11 Jan 2013 16:56
Last Modified:25 May 2017 23:05

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