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Studies of inorganic crystals in biological tissue magnetite in human tumors

Kobayashi, Atsuko and Yamamoto, Naoichi and Kirschvink, Joseph L. (1997) Studies of inorganic crystals in biological tissue magnetite in human tumors. Journal of the Japan Society of Powder Metallurgy, 44 (3). pp. 294-300. ISSN 0532-8799.

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Ferromagnetic materials, magnetite crystals, have been extracted and identified from magnetotactic bacteria, polyplacophoran mollusks (chitons), salmons, tuna and recently tissues of the human brain. Ferritin, the iron storage nonheme-protein contains hydrated iron oxide (Fe_2O_3 • nH_2O) in its core. It is suggested that this hydrated oxide in ferritin would be the precursor of magnetite in both magnetotactic bacteria and the chitons. Many studies have described that ferritin were related with cell proliferation, specially tumor cell growth. In this study, we attempted to investigate the presence of magnetite in tumor tissues. We report the first detection of magnetic materials in various human tumor tissues (melanoma, breast, ovary, testicle, sarcoma, meninginoma, glioblastoma, astrocytoma, glioma, metastasis) with the use of SQUID magnetometry. The magnetometory data for the magnetic materials are consistent with magnetite (Fe_3O_4). Its concentration of various tissue types were measured via sIRMs. Tumor tissues were also stained blue with the Perls staining method for detecting ferritin. Our experiments show that the distribution of magnetite and ferritin in tumor tissues might depend on the etiology of the tumor. Ferritin distribution as indicated through staining suggest an irregular pattern with distinctive foci. However, a spacial covariance between ferritin and magnetite was unable to demonstrate in this study.

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Kirschvink, Joseph L.0000-0001-9486-6689
Additional Information:© 1997 Japan Society of Powder and Powder Metallurgy. This work was partially supported by EPRI (Electric Power Research Institute) WO 4307-03 and NIH (National Institue of Health) grant ES-06652.
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Electric Power Research Institute (EPRI)WO 4307-03
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:36336
Deposited By: Tony Diaz
Deposited On:16 Jan 2013 19:53
Last Modified:24 Jan 2020 22:18

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