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Active Self-Assembly of Algorithmic Shapes and Patterns in Polylogarithmic Time

Woods, Damien and Chen, Ho-Lin and Goodfriend, Scott and Dabby, Nadine and Winfree, Erik and Yin, Peng (2013) Active Self-Assembly of Algorithmic Shapes and Patterns in Polylogarithmic Time. In: Proceedings of the 4th conference on Innovations in Theoretical Computer Science. ACM , New York, NY, pp. 353-354. ISBN 978-1-4503-1859-4. https://resolver.caltech.edu/CaltechAUTHORS:20130128-100842529

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Abstract

We describe a computational model for studying the complexity of self-assembled structures with active molecular components. Our model captures notions of growth and movement ubiquitous in biological systems. The model is inspired by biology's fantastic ability to assemble biomolecules that form systems with complicated structure and dynamics, from molecular motors that walk on rigid tracks and proteins that dynamically alter the structure of the cell during mitosis, to embryonic development where large-scale complicated organisms efficiently grow from a single cell. Using this active self-assembly model, we show how to efficiently self-assemble shapes and patterns from simple monomers. For example, we show how to grow a line of monomers in time and number of monomer states that is merely logarithmic in the length of the line. Our main results show how to grow arbitrary connected two-dimensional geometric shapes and patterns in expected time that is polylogarithmic in the size of the shape, plus roughly the time required to run a Turing machine deciding whether or not a given pixel is in the shape. We do this while keeping the number of monomer types logarithmic in shape size, plus those monomers required by the Kolmogorov complexity of the shape or pattern. This work thus highlights the efficiency advantages of active self-assembly over passive self-assembly and motivates experimental effort to construct general-purpose active molecular self-assembly systems.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://arxiv.org/abs/1301.2626arXivUNSPECIFIED
http://dx.doi.org/10.1145/2422436.2422476DOIUNSPECIFIED
http://dl.acm.org/citation.cfm?doid=2422436.2422476PublisherUNSPECIFIED
ORCID:
AuthorORCID
Winfree, Erik0000-0002-5899-7523
Additional Information:© 2013 held by the author/owner(s). ITCS’13, January 9–12, 2013, Berkeley, California, USA. ACM 978-1-4503-1859-4/13/01. Supported by NSF grants CCF-1219274, CCF-1162589, and 0832824|the Molecular Programming Project, an NSF Graduate Fellowship, and The Caltech Center for Biological Circuit Design. Many thanks to Niles Pierce and Patrick Mullen for valuable discussions.
Funders:
Funding AgencyGrant Number
NSFCCF-1219274
NSFCCF-1162589
NSF Molecular Programming Project0832824
NSF Graduate FellowshipUNSPECIFIED
Caltech Center for Biological Circuit DesignUNSPECIFIED
Record Number:CaltechAUTHORS:20130128-100842529
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130128-100842529
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:36616
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:28 Jan 2013 19:35
Last Modified:03 Oct 2019 04:39

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