Lu, Bo and Zhu, Danhong and Hinton, David and Humayun, Mark S. and Tai, Yu-Chong (2012) A 3D parylene scaffold cage for culturing retinal pigment epithelial cells. In: 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems. IEEE , Piscataway, NJ, pp. 741-744. ISBN 978-1-4673-0325-5. https://resolver.caltech.edu/CaltechAUTHORS:20130201-100453140
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Abstract
This work reports a 3D parylene scaffold cage for culturing stem-cell-differentiated retinal pigment epithelial (RPE) cells for the therapy of age-related macular degeneration, which is caused by degenerated permeability of the Bruch's membrane first and then the loss of RPE cells. This reported cage can support sufficient nutrient permeation to nourish the RPE cells inside with in vivo like morphology. Compared to previous single layer scaffold substrates, this cage can effectively prevent the undesirable cell migration away from the scaffold.
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| Additional Information: | © 2012 IEEE. Date of Current Version: 15 March 2012. This work is supported by the California Institute of Regenerative Medicine (CIRM); Disease Team Award; Grant DR1-01444. | |||||||||
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| DOI: | 10.1109/MEMSYS.2012.6170292 | |||||||||
| Record Number: | CaltechAUTHORS:20130201-100453140 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20130201-100453140 | |||||||||
| Official Citation: | Bo Lu; Danhong Zhu; Hinton, D.; Humayun, M.S.; Yu-chong Tai; , "A 3D parylene scaffold cage for culturing retinal pigment epithelial cells," Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on , vol., no., pp.741-744, Jan. 29 2012-Feb. 2 2012 doi: 10.1109/MEMSYS.2012.6170292 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 36731 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 25 Feb 2013 23:24 | |||||||||
| Last Modified: | 09 Nov 2021 23:24 |
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