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Octopamine Neurons Mediate Flight-Induced Modulation of Visual Processing in Drosophila

Suver, Marie P. and Mamiya, Akira and Dickinson, Michael H. (2012) Octopamine Neurons Mediate Flight-Induced Modulation of Visual Processing in Drosophila. Current Biology, 22 (24). pp. 2294-2302. ISSN 0960-9822. https://resolver.caltech.edu/CaltechAUTHORS:20130205-104129299

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Abstract

Background: Activity-dependent modulation of sensory systems has been documented in many organisms and is likely to be essential for appropriate processing of information during different behavioral states. However, the mechanisms underlying these phenomena remain poorly characterized. Results: We investigated the role of octopamine neurons in the flight-dependent modulation observed in visual interneurons in Drosophila. The vertical system (VS) cells exhibit a boost in their response to visual motion during flight compared to quiescence. Pharmacological application of octopamine evokes responses in quiescent flies that mimic those observed during flight, and octopamine cells that project to the optic lobes increase in activity during flight. Using genetic tools to manipulate the activity of octopamine neurons, we find that they are both necessary and sufficient for the flight-induced visual boost. Conclusions: This study provides the first evidence that endogenous release of octopamine is involved in state-dependent modulation of visual interneurons in flies.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cub.2012.10.034DOIArticle
ORCID:
AuthorORCID
Suver, Marie P.0000-0003-4491-6996
Dickinson, Michael H.0000-0002-8587-9936
Additional Information:© 2012 Elsevier Ltd. Received: September 28, 2012; Revised: October 15, 2012; Accepted: October 16, 2012; Published: November 8, 2012. We would like to thank Anne Sustar for the confocal image of the Tdc2-Gal4 line and for helpful comments and aid in setting up fly lines for the paper. We would also like to thank Gaby Maimon for helpful discussion. This work was supported by grants from the National Science Foundation (0623527), the Air Force Office of Scientific Research (FA9550-10-1-0368), and the Paul G. Allen Family Foundation (all to M.H.D.).
Funders:
Funding AgencyGrant Number
NSF0623527
Air Force Office of Scientific Research (AFOSR)FA9550-10-1-0368
Paul G. Allen Family FoundationUNSPECIFIED
Issue or Number:24
Record Number:CaltechAUTHORS:20130205-104129299
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130205-104129299
Official Citation:Marie P. Suver, Akira Mamiya, Michael H. Dickinson, Octopamine Neurons Mediate Flight-Induced Modulation of Visual Processing in Drosophila, Current Biology, Volume 22, Issue 24, 18 December 2012, Pages 2294-2302, ISSN 0960-9822, 10.1016/j.cub.2012.10.034.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:36776
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:05 Feb 2013 21:11
Last Modified:29 Oct 2019 22:17

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