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Gastrointestinal symptoms and probiotic treatment in a mouse model of an autism risk factor

Hsiao, Elaine Y. and McBride, Sara W. and Hsien, Sophia and Chow, Janet and Mazmanian, Sarkis K. and Patterson, Paul H. (2012) Gastrointestinal symptoms and probiotic treatment in a mouse model of an autism risk factor. Journal of Neuroimmunology, 253 (1-2). pp. 47-48. ISSN 0165-5728. doi:10.1016/j.jneuroim.2012.10.001.

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Objective: While autism is a neurodevelopmental disorder characterized by language and social deficits, recent studies have highlighted striking dysregulation in the neural, peripheral, and enteric immune systems of autistic individuals. There are also reports that subsets of children with autism spectrum disorder (ASD) display gastrointestinal (GI) abnormalities, including chronic inflammation of the colon, increased intestinal permeability and altered composition of GI microbiota. Moreover, antibiotic treatment and restricted diet are reported to provide behavioral improvements for some ASD children. We use a mouse model of an ASD risk factor, maternal immune activation (MIA), to assess whether offspring, which display core behavioral and neuropathological features of autism, also display ASD-associated GI symptoms. To explore the potential connections between GI problems and the brain and behavior,we test whether postnatal administration of a probiotic influences GI and ASD-related behaviors.

Item Type:Article
Related URLs:
URLURL TypeDescription
Hsiao, Elaine Y.0000-0002-1633-588X
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2012 Elsevier B.V.
Issue or Number:1-2
Record Number:CaltechAUTHORS:20130208-111108964
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Official Citation:ISNI 2012 Abstracts: B cells and antibodies, Journal of Neuroimmunology, Volume 253, Issues 1–2, 15 December 2012, Pages 1-195, ISSN 0165-5728, 10.1016/j.jneuroim.2012.10.001.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:36820
Deposited By: Tony Diaz
Deposited On:08 Feb 2013 23:22
Last Modified:09 Nov 2021 23:24

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