A Caltech Library Service

Functional implications of hypothalamic neurogenesis in the adult mammalian brain

Lee, Daniel A. and Blackshaw, Seth (2012) Functional implications of hypothalamic neurogenesis in the adult mammalian brain. International Journal of Developmental Neuroscience, 30 (8). pp. 615-621. ISSN 0736-5748. PMCID PMC3906127. doi:10.1016/j.ijdevneu.2012.07.003.

[img] PDF - Accepted Version
See Usage Policy.


Use this Persistent URL to link to this item:


Adult neurogenesis represents a striking example of structural plasticity in the mature brain. Research on adult mammalian neurogenesis today focuses almost exclusively on two areas: the subgranular zone (SGZ) in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ) of the lateral ventricles. Numerous studies, however, have also reported adult neurogenesis in the hypothalamus, a brain structure that serves as a central homeostatic regulator of numerous physiological and behavioral functions, such as feeding, metabolism, body temperature, thirst, fatigue, aggression, sleep, circadian rhythms, and sexual behavior. Recent studies on hypothalamic neurogenesis have identified a progenitor population within a dedicated hypothalamic neurogenic zone. Furthermore, adult born hypothalamic neurons appear to play a role in the regulation of metabolism, weight, and energy balance. It remains to be seen what other functional roles adult hypothalamic neurogenesis may play. This review summarizes studies on the identification and characterization of neural stem/progenitor cells in the mammalian hypothalamus, in what contexts these stem/progenitor cells engage in neurogenesis, and potential functions of postnatally generated hypothalamic neurons.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle CentralArticle
Lee, Daniel A.0000-0001-7411-2740
Additional Information:© 2012 ISDN. Published by Elsevier Ltd. Received 23 April 2012; Received in revised form 12 July 2012; Accepted 14 July 2012. We thank J. Bedont, E. Newman, and T. Pak for helpful comments on the manuscript and figures. This work was supported by a Basil O’Connor Starter Scholar Award and grants from the Klingenstein Fund and NARSAD (to S.B.). S.B. is a W.M. Keck Distinguished Young Scholar in Medical Research.
Funding AgencyGrant Number
Basil O’Connor Starter Scholar AwardUNSPECIFIED
Klingenstein FundUNSPECIFIED
W. M. Keck FoundationUNSPECIFIED
Subject Keywords:Hypothalamus; Neurogenesis; Neural progenitors; Stem cells; Adult; Function; Tanycytes; Development; Metabolism; Energy balance; Ventricular zone
Issue or Number:8
PubMed Central ID:PMC3906127
Record Number:CaltechAUTHORS:20130221-095820905
Persistent URL:
Official Citation:Daniel A. Lee, Seth Blackshaw, Functional implications of hypothalamic neurogenesis in the adult mammalian brain, International Journal of Developmental Neuroscience, Volume 30, Issue 8, December 2012, Pages 615-621, ISSN 0736-5748, 10.1016/j.ijdevneu.2012.07.003.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37045
Deposited By: Tony Diaz
Deposited On:22 Feb 2013 23:46
Last Modified:09 Nov 2021 23:26

Repository Staff Only: item control page