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Temperature-insensitive detection of low-concentration nanoparticles using a functionalized high-Q microcavity

Jin, Wei-Liang and Yi, Xu and Hu, Yi-Wen and Li, Bei-Bei and Xiao, Yun-Feng (2013) Temperature-insensitive detection of low-concentration nanoparticles using a functionalized high-Q microcavity. Applied Optics, 52 (2). pp. 155-161. ISSN 0003-6935. http://resolver.caltech.edu/CaltechAUTHORS:20130226-094834729

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Abstract

The ability to detect nanoparticles in extremely dilute solutions in the presence of environmental noise is crucial for biosensing applications. In this paper we propose a scheme for detecting target nanoparticles through their scattering effects in a high-Q whispering gallery microcavity. The detection signal, defined as the total linewidth broadening of the two new split modes that appear upon nanoparticle adsorption, is highly sensitive and proportional to the nanoparticle concentration. Furthermore, this new method of detection eliminates the requirement for strict temperature control and is capable of distinguishing the signal from the biorecognitions (e.g., antibodies) initially attached to the resonator and that from the target nanoparticles (e.g., antigens).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/AO.52.000155DOIArticle
http://www.opticsinfobase.org/ao/abstract.cfm?uri=ao-52-2-155PublisherArticle
ORCID:
AuthorORCID
Yi, Xu0000-0002-2485-1104
Additional Information:© 2013 Optical Society of America. Received 5 September 2012; revised 23 November 2012; accepted 27 November 2012; posted 29 November 2012 (Doc. ID 175531); published 4 January 2013. B.-B. Li thanks William Clements for the helpful discussion and the paper revision. The authors acknowledge financial support from the National Natural Science Foundation of China under grant nos. 11004003, 11121091, and 11222440. Y.-F. Xiao was also supported by the Research Fund for the Doctoral Program of Higher Education (no. 20090001120004).
Funders:
Funding AgencyGrant Number
National Natural Science Foundation of China11004003
National Natural Science Foundation of China11121091
National Natural Science Foundation of China11222440
Research Fund for the Doctoral Program of Higher Education 20090001120004
Classification Code:OCIS Codes: 290.0290, 140.3948, 280.4788
Record Number:CaltechAUTHORS:20130226-094834729
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130226-094834729
Official Citation:Wei-Liang Jin, Xu Yi, Yi-Wen Hu, Bei-Bei Li, and Yun-Feng Xiao, "Temperature-insensitive detection of low-concentration nanoparticles using a functionalized high-Q microcavity," Appl. Opt. 52, 155-161 (2013) http://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-52-2-155
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37135
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:26 Feb 2013 19:51
Last Modified:31 Oct 2017 21:04

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