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Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

Pieper, Ursula and Schlessinger, Avner and Kloppmann, Edda and Chang, Geoffrey A. and Chou, James J. and Dumont, Mark E. and Fox, Brian G. and Fromme, Petra and Hendrickson, Wayne A. and Malkowski, Michael G. and Rees, Douglas C. and Stokes, David L. and Stowell, Michael H. B. and Wiener, Michael C. and Rost, Burkhard and Stroud, Robert M. and Stevens, Raymond C. and Sali, Andrej (2013) Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nature Structural & Molecular Biology, 20 (2). pp. 135-138. ISSN 1545-9985. PMCID PMC3645303. doi:10.1038/nsmb.2508.

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Given the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, providing structure and function information not otherwise available.

Item Type:Article
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Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. Received 16 August 2012; accepted 9 January 2013; published online 5 February 2013. We thank I. Wilson, H. Berman, J. Chin and P. Preusch for critical comments on the manuscript. Research was supported by the US National Institutes of Health PSI:Biology grants U54 GM094662 (A.S., U.P.), U54 GM094618 (R.C.S.), U54 GM094625 (R.M.S., A.S., U.P.), U54 GM094584 (B.G.F.), U54 GM094599 (P.F.), U54 GM094611 (M.C.W., M.E.D., M.G.M.), U54 GM094610 (G.A.C., D.C.R., M.H.B.S.), U54 GM094608 (J.J.C.), U54 GM095315 (W.A.H., B.R., E.K.) and U54 GM094598 (D.L.S.).
Funding AgencyGrant Number
NIHU54 GM094662
NIHU54 GM094618
NIHU54 GM094625
NIHU54 GM094584
NIHU54 GM094599
NIHU54 GM094611
NIHU54 GM094610
NIHU54 GM094608
NIHU54 GM095315
NIHU54 GM094598
Issue or Number:2
PubMed Central ID:PMC3645303
Record Number:CaltechAUTHORS:20130307-133554833
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37376
Deposited By: Jason Perez
Deposited On:08 Mar 2013 00:05
Last Modified:09 Nov 2021 23:28

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