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Computational multiscale modeling of embryo development

Krupinski, Pawel and Chickarmane, Vijay and Peterson, Carsten (2012) Computational multiscale modeling of embryo development. Current Opinion in Genetics and Development, 22 (6). pp. 613-618. ISSN 1879-0380. doi:10.1016/j.gde.2012.08.006.

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Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell–cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.

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Additional Information:© 2012 Elsevier Ltd. Available online 6th September 2012. This work was supported (CP and PK) by the Swedish Foundation for Strategic Research (Senior Individual Grant A3 06:215). VC would like to acknowledge support from Prof. Elliot Meyerowitz.
Funding AgencyGrant Number
Swedish Foundation for Strategic ResearchA3 06:215
Issue or Number:6
Record Number:CaltechAUTHORS:20130308-095533854
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Official Citation:Pawel Krupinski, Vijay Chickarmane, Carsten Peterson, Computational multiscale modeling of embryo development, Current Opinion in Genetics & Development, Volume 22, Issue 6, December 2012, Pages 613-618, ISSN 0959-437X, 10.1016/j.gde.2012.08.006.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37410
Deposited By: Tony Diaz
Deposited On:04 Apr 2013 23:50
Last Modified:09 Nov 2021 23:28

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