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Redox-Active Antibiotics Control Gene Expression and Community Behavior in Divergent Bacteria

Dietrich, Lars E. P. and Teal, Tracy K. and Price-Whelan, Alexa and Newman, Dianne K. (2008) Redox-Active Antibiotics Control Gene Expression and Community Behavior in Divergent Bacteria. Science, 321 (5893). pp. 1203-1206. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20130312-105735972

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Abstract

It is thought that bacteria excrete redox-active pigments as antibiotics to inhibit competitors. In Pseudomonas aeruginosa, the endogenous antibiotic pyocyanin activates SoxR, a transcription factor conserved in Proteo- and Actinobacteria. In Escherichia coli, SoxR regulates the superoxide stress response. Bioinformatic analysis coupled with gene expression studies in P. aeruginosa and Streptomyces coelicolor revealed that the majority of SoxR regulons in bacteria lack the genes required for stress responses, despite the fact that many of these organisms still produce redox-active small molecules, which indicates that redox-active pigments play a role independent of oxidative stress. These compounds had profound effects on the structural organization of colony biofilms in both P. aeruginosa and S. coelicolor, which shows that "secondary metabolites" play important conserved roles in gene expression and development.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1160619 DOIUNSPECIFIED
http://www.sciencemag.org/content/321/5893/1203PublisherUNSPECIFIED
ORCID:
AuthorORCID
Newman, Dianne K.0000-0003-1647-1918
Additional Information:© 2008 American Association for the Advancement of Science. Received 19 May 2008; accepted 24 July 2008. We thank P. Straight (Harvard University); M. Bibb and A. Hesketh (John Innes Centre, UK) for providing S. coelicolor A3(2) strains M145 and M512; and N. C. Caiazza, C. T. Brown, and B. Wold for helpful discussions. This work was supported by an EMBO Long Term Fellowship (L.E.P.D.) and grants from the Packard Foundation and Howard Hughes Medical Institute (D.K.N.).
Funders:
Funding AgencyGrant Number
EMBO Long Term Fellowship UNSPECIFIED
Packard Foundation UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Record Number:CaltechAUTHORS:20130312-105735972
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130312-105735972
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37467
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Mar 2013 21:20
Last Modified:24 Oct 2017 15:13

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