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Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics

Price-Whelan, Alexa and Dietrich, Lars E. P. and Newman, Dianne K. (2006) Rethinking 'secondary' metabolism: physiological roles for phenazine antibiotics. Nature Chemical Biology, 2 (2). pp. 71-78. ISSN 1552-4450.

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Microorganisms exist in the environment as multicellular communities that face the challenge of surviving under nutrient-limited conditions. Chemical communication is an essential part of the way in which these populations coordinate their behavior, and there has been an explosion of understanding in recent years regarding how this is accomplished. Much less, however, is understood about the way these communities sustain their metabolism. Bacteria of the genus Pseudomonas are ubiquitous, and are distinguished by their production of colorful secondary metabolites called phenazines. In this article, we suggest that phenazines, which are produced under conditions of high cell density and nutrient limitation, may be important for the persistence of pseudomonads in the environment.

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Price-Whelan, Alexa0000-0003-0872-7098
Newman, Dianne K.0000-0003-1647-1918
Additional Information:© 2006 Nature Publishing Group. Published online 18 January 2006; corrected 7 March 2006. The work was supported by an NIH training grant (A. P.-W.) and a postdoctoral EMBO fellowship (L.E.P.D.) administered by the California Institute of Technology, the Howard Hughes Medical Institute (D.K.N.) and the Packard Foundation.
Funding AgencyGrant Number
Caltech EMBO fellowshipUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20130312-140213883
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37475
Deposited By: Tony Diaz
Deposited On:13 Mar 2013 21:12
Last Modified:09 Mar 2020 13:19

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