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arrA Is a Reliable Marker for As(V) Respiration

Malasarn, D. and Saltikov, C. W. and Campbell, K. M. and Santini, J. M. and Hering, J. G. and Newman, D. K. (2004) arrA Is a Reliable Marker for As(V) Respiration. Science, 306 (5695). p. 455. ISSN 0036-8075.

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Arsenate [As(V)]-respiring bacteria affect the speciation and mobilization of arsenic in the environment. This can lead to arsenic contamination of drinking water supplies and deleterious consequences for human health. Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments. The expression of arrA thus can be used to monitor sites in which As(V)-respiring bacteria may be controlling arsenic geochemistry.

Item Type:Article
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Newman, D. K.0000-0003-1647-1918
Additional Information:© 2004 American Association for the Advancement of Science. Received 6 July 2004; accepted 16 August 2004. We thank R. Oremland, F. Rosenzweig, and C. House for sending us strains. All new arrA gene sequences have been deposited in GenBank. Accession numbers are available in supporting online material. Supported by the Luce and Packard Foundations (D.K.N.) and NSF award nos. BES-0201888 (J.G.H.) and DBI-0200145 (C.W.S.).
Funding AgencyGrant Number
Luce FoundationUNSPECIFIED
Packard FoundationUNSPECIFIED
Issue or Number:5695
Record Number:CaltechAUTHORS:20130313-141728101
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37505
Deposited By: Tony Diaz
Deposited On:14 Mar 2013 18:40
Last Modified:03 Oct 2019 04:48

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