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Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium

Hollmann, Joseph L. and Horstmeyer, Roarke and Yang, Changhuei and DiMarzio, Charles A. (2013) Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium. Journal of Biomedical Optics, 18 (2). Art. No. 025004. ISSN 1083-3668. doi:10.1117/1.JBO.18.2.025004.

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The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling through the US beam waist is frequency shifted and may be isolated with demodulation. This paper utilizes a multiphysics simulation to model the optical and US interactions in both synthetic tissue and random scattering media. The results illustrate that optical energy may be focused within a turbid medium utilizing a US guidestar. The results also suggest that optical energy travels preferentially along optical channels within a turbid medium.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle
Horstmeyer, Roarke0000-0002-2480-9141
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2013 Society of Photo-Optical Instrumentation Engineers. Paper 12444RR received Jul. 12, 2012; revised manuscript received Jan. 7, 2013; accepted for publication Jan. 24, 2013; published online Feb. 12, 2013. C. DiMarzio and J. Hollmann acknowledge support from CenSSIS, the Gordon Center for Subsurface Sensing and Imaging Systems, under the Engineering Research Centers Program of the National Science Foundation (award number EEC-9986821). R. Horstmeyer acknowledges support from the National Defense Science and Engineering Graduate fellowship awarded through the Air Force Office of Scientific Research.
Funding AgencyGrant Number
National Defense Science and Engineering Graduate (NDSEG) FellowshipUNSPECIFIED
Air Force Office of Scientific Research (AFOSR)UNSPECIFIED
Subject Keywords:ultrasound modulation of light; guidestar; turbidity suppression; finite-difference time-domain; tissue model
Issue or Number:2
Record Number:CaltechAUTHORS:20130326-091254901
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37623
Deposited By: Tony Diaz
Deposited On:26 Mar 2013 23:09
Last Modified:09 Nov 2021 23:30

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