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Bacterial Respiration of Arsenate and Its Significance in the Environment

Oremland, Ronald S. and Newman, Dianne K. and Kail, Brian W. and Stolz, John F. (2002) Bacterial Respiration of Arsenate and Its Significance in the Environment. In: Environmental Chemistry of Arsenic. Books in soils, plants, and the environment. Marcel Dekker , New York, pp. 273-295. ISBN 9780824706760. https://resolver.caltech.edu/CaltechAUTHORS:20130327-123845559

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Abstract

Although arsenic is a trace element in terms of its natural abundance, it nonetheless has a common presence within the earth's crust. Because it is classified as a group VB element in the periodic table, it shares many chemical and biochemical properties in common with its neighbors phosphorus and nitrogen. Indeed, in the case of this element's most oxidized (+5) oxidation state, arsenate [HAsO_4^(2-) or As (V)], its toxicity is based on its action as an analog of phosphate. Hence, arsenate ions uncouple the oxidative phosphorylation normally associated with the enzyme glyceraldehyde 3-phosphate dehydrogenase, thereby preventing the formation ofphosphoglyceroyl phosphate, a key high-energy intermediate in glycolysis. To guard against this, a number of bacteria possess a detoxifying arsenate reductase pathway (the arsC system) whereby cytoplasmic enzymes remove internal pools of arsenate by achieving its reduction to arsenite [H_2AsO_3- or As (III)]. However, because the arsenite product binds with internal sulfhydryl groups that render it even more toxic than the original arsenate, efficient arsenite efflux from the cell is also required and is achieved by an active ion ''pumping'' system (1). The details of this bacterial arsenic detoxification phenomenon have been well established in the literature, and Chapter 10 in this volume provided a thorough review. Here, we discuss bacterial respiration of arsenate and its significance in the environment. As a biological phenomenon, respiratory growth on arsenate is quite remarkable, given the toxicity of the element. Moreover, the consequences of microbial arsenate respiration may, at times, have a significant impact on environmental chemistry.


Item Type:Book Section
ORCID:
AuthorORCID
Newman, Dianne K.0000-0003-1647-1918
Additional Information:© 2002 Marcel Dekker. We thank Prof. H. L. Ehrlich and Prof. L. Young for helpful comments on an earlier draft of this manuscript.
Series Name:Books in soils, plants, and the environment
Record Number:CaltechAUTHORS:20130327-123845559
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130327-123845559
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37652
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Jul 2013 22:50
Last Modified:03 Oct 2019 04:49

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