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Gene duplications and the early evolution of neural crest development

Green, Stephen A. and Bronner, Marianne E. (2013) Gene duplications and the early evolution of neural crest development. Seminars in Cell and Developmental Biology, 24 (2). pp. 95-100. ISSN 1084-9521. doi:10.1016/j.semcdb.2012.12.006.

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Neural crest cells are an important cell type present in all vertebrates, and elaboration of the neural crest is thought to have been a key factor in their evolutionary success. Genomic comparisons suggest there were two major genome duplications in early vertebrate evolution, raising the possibility that evolution of neural crest was facilitated by gene duplications. Here, we review the process of early neural crest formation and its underlying gene regulatory network (GRN) as well as the evolution of important neural crest derivatives. In this context, we assess the likelihood that gene and genome duplications capacitated neural crest evolution, particularly in light of novel data arising from invertebrate chordates.

Item Type:Article
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Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2013 Elsevier Ltd. Available online 31 December 2012. We would like to thank the members of the Bronner Laboratory for their helpful comments. This work was supported by DE017911 and GM090049.
Funding AgencyGrant Number
Subject Keywords:Neural crest; Evolution; Gene duplication
Issue or Number:2
Record Number:CaltechAUTHORS:20130328-084449579
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Official Citation:Stephen A. Green, Marianne E. Bronner, Gene duplications and the early evolution of neural crest development, Seminars in Cell & Developmental Biology, Volume 24, Issue 2, February 2013, Pages 95-100, ISSN 1084-9521, 10.1016/j.semcdb.2012.12.006.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37663
Deposited By: Tony Diaz
Deposited On:12 Apr 2013 23:26
Last Modified:09 Nov 2021 23:30

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