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Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months

Elison, Jed T. and Wolff, Jason J. and Heimer, Debra C. and Paterson, Sarah J. and Gu, Hongbin and Hazlett, Heather C. and Styner, Martin and Gerig, Guido and Piven, Joseph (2013) Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months. Developmental Science, 16 (2). pp. 186-197. ISSN 1363-755X. PMCID PMC3582040. https://resolver.caltech.edu/CaltechAUTHORS:20130404-141131200

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Abstract

Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9- to 10-month period as a time interval of maximal individual differences. We then demonstrate that fractional anisotropy in the right uncinate fasciculus, a white matter fiber bundle connecting the amygdala to the ventral-medial prefrontal cortex and anterior temporal pole, measured in 6-month-olds predicts individual differences in responding to joint attention at 9 months of age. The white matter microstructure of the right uncinate was not related to receptive language ability at 9 months. These findings suggest that the development of core nonverbal social communication skills in infancy is largely supported by preceding developments within right lateralized frontotemporal brain systems.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/desc.12015DOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/desc.12015/abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582040PubMed CentralArticle
Additional Information:© 2012 Blackwell Publishing Ltd. Issue published online: 23 February 2013; Article first published online: 20 December 2012; Manuscript Accepted: 2 September 2012; Manuscript Received: 11 June 2012. This research was supported by grants awarded to JP from NIH/NICHD (Autism Center of Excellence R01 #HD055741; IDDRC, P30, #HD03110), and the Foundation of Hope. JJW and DCH were supported by an NIH training grant (T32-HD40127) and JTE was supported by an NRSA award (5-T32-HD007376) from NICHD. The authors declare no competing financial interests. We thank the families who participated in this work and Whitney Weigold for her contribution to data collection.
Funders:
Funding AgencyGrant Number
NIHR01 HD055741
NIHR01 HD03110
Foundation of HopeUNSPECIFIED
NIH Predoctoral FellowshipT32-HD40127
NIH Predoctoral Fellowship5-T32-HD007376
Issue or Number:2
PubMed Central ID:PMC3582040
Record Number:CaltechAUTHORS:20130404-141131200
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130404-141131200
Official Citation:Elison, J. T., Wolff, J. J., Heimer, D. C., Paterson, S. J., Gu, H., Hazlett, H. C., Styner, M., Gerig, G., Piven, J. and for the IBIS Network (2013), Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months. Developmental Science, 16: 186–197. doi: 10.1111/desc.12015
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37768
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:04 Apr 2013 22:20
Last Modified:03 Oct 2019 04:50

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