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Endogenous Phenazine Antibiotics Promote Anaerobic Survival of Pseudomonas aeruginosa via Extracellular Electron Transfer

Wang, Yun and Kern, Suzanne E. and Newman, Dianne K. (2010) Endogenous Phenazine Antibiotics Promote Anaerobic Survival of Pseudomonas aeruginosa via Extracellular Electron Transfer. Journal of Bacteriology, 192 (1). pp. 365-369. ISSN 0021-9193. PMCID PMC2798253. http://resolver.caltech.edu/CaltechAUTHORS:20130405-104044575

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Abstract

Antibiotics are increasingly recognized as having other, important physiological functions for the cells that produce them. An example of this is the effect that phenazines have on signaling and community development for Pseudomonas aeruginosa (L. E. Dietrich, T. K. Teal, A. Price-Whelan, and D. K. Newman, Science 321:1203-1206, 2008). Here we show that phenazine-facilitated electron transfer to poised-potential electrodes promotes anaerobic survival but not growth of Pseudomonas aeruginosa PA14 under conditions of oxidant limitation. Other electron shuttles that are reduced but not made by PA14 do not facilitate survival, suggesting that the survival effect is specific to endogenous phenazines.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1128/JB.01188-09 DOIArticle
http://jb.asm.org/content/192/1/365PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798253/PubMed CentralArticle
ORCID:
AuthorORCID
Newman, Dianne K.0000-0003-1647-1918
Additional Information:© 2010 American Society for Microbiology. Received 2 September 2009; Accepted 24 October 2009. Published ahead of print on 30 October 2009. We thank Jordan Katz for his help with making the Pt mesh counter electrodes and Alexa Price-Whelan and other Newman lab members for discussions. This work was supported by grants to D.K.N. from the Packard Foundation and Howard Hughes Medical Institute and an NSF graduate research fellowship to S.E.K. D.K.N. is an Investigator with the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Packard FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NSF graduate research fellowshipUNSPECIFIED
PubMed Central ID:PMC2798253
Record Number:CaltechAUTHORS:20130405-104044575
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20130405-104044575
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37784
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:08 Apr 2013 14:37
Last Modified:24 Oct 2017 15:54

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