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Animals in a bacterial world, a new imperative for the life sciences

McFall-Ngai, Margaret and Hadfield, Michael G. and Bosch, Thomas C. G. and Carey, Hannah V. and Domazet-Lošo, Tomislav and Douglas, Angela E. and Dubilier, Nicole and Eberl, Gerard and Fukami, Tadashi and Gilbert, Scott F. and Hentschel, Ute and King, Nicole and Kjellerberg, Staffan and Knoll, Andrew H. and Kremer, Natacha and Mazmanian, Sarkis K. and Metcalf, Jessica L. and Nealson, Kenneth and Pierce, Naomi E. and Rawls, John F. and Reid, Ann and Ruby, Edward G. and Rumpho, Mary and Sanders, Jon G. and Tautz, Diethard and Wernegreen, Jennifer J. (2013) Animals in a bacterial world, a new imperative for the life sciences. Proceedings of the National Academy of Sciences of the United States of America, 110 (9). pp. 3229-3236. ISSN 0027-8424. PMCID PMC3587249. doi:10.1073/pnas.1218525110.

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In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal–bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other’s genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal–bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.

Item Type:Article
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URLURL TypeDescription DOIArticle CentralArticle
Dubilier, Nicole0000-0002-9394-825X
Knoll, Andrew H.0000-0003-1308-8585
Mazmanian, Sarkis K.0000-0003-2713-1513
Nealson, Kenneth0000-0001-5189-3732
Additional Information:© 2013 National Academy of Sciences. Edited by David M. Karl, University of Hawaii, Honolulu, HI, and approved January 17, 2013 (received for review December 2, 2012). Published online before print February 7, 2013. We thank N. Glasser for assistance with graphics and D. Haraway and E. A. C. Heath- Heckman for helpful discussion and comments on the manuscript. The work of this group was supported by National Science Foundation Grant EF-0905606 to the National Evolutionary Synthesis Center (NESCent). This effort was also supported by fellowships to M.M.-N. from the John Simon Guggenheim Foundation and the Gordon and Betty Moore Foundation Visiting Scholar Program at the California Institute of Technology. Author contributions: M.M.-N., M.G.H., T.C.G.B., H.V.C., T.D.-L., A.E.D., N.D., G.E., T.F., S.F.G., U.H., N. King, S.K., A.H.K., N. Kremer, S.K.M., J.L.M., K.N., N.E.P., J.F.R., A.R., E.G.R., M.R., J.G.S., D.T., and J.J.W. wrote the paper.
Funding AgencyGrant Number
John Simon Guggenheim FoundationUNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:bacterial roles animal origins; reciprocal effects animal–bacterial genomics; bacteria-driven development; microbiome and host physiology; nested ecosystems
Issue or Number:9
PubMed Central ID:PMC3587249
Record Number:CaltechAUTHORS:20130408-133301756
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37809
Deposited By: Jason Perez
Deposited On:08 Apr 2013 23:19
Last Modified:09 Nov 2021 23:31

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