A Caltech Library Service

Electrospun nanofibrous scaffolds for the promotion of scarfree corneal wound healing

Fu, Amy and Kornfield, Julia A. (2013) Electrospun nanofibrous scaffolds for the promotion of scarfree corneal wound healing. In: 245th ACS National Meeting & Exposition, Abstracts of Papers, April 7-11, 2013, New Orleans, LA.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Irregular healing following corneal injury accounts for approx. 1.5 million new cases of monocular blindness every year. Unlike cataracts, such cases of blindness are irreversible without corneal transplantation. Efforts to develop biomaterials that promote wound healing have been largely unsuccessful for corneal applications, where stringent optical requirements necessitate a transparent wound dressing to promote host-cell infiltration and foster scar-free tissue remodeling. We approach this problem with a novel proteinpolymer scaffold that contains nanofibrillar elements characteristic of the highly-ordered structure of a healthy corneal stroma. To evaluate the role of this fibrillar nanostructure, we examine cell responses to electrospun nanofiber mats both in-vitro and in-vivo. We show that the material is well-suited for corneal applications because of its transparency, ability to recruit epithelial and fibroblast cells and capability to regulate the fibroblast repair phenotype.

Item Type:Conference or Workshop Item (Paper)
Related URLs:
URLURL TypeDescription website
Kornfield, Julia A.0000-0001-6746-8634
Additional Information:© 2013 American Chemical Society.
Record Number:CaltechAUTHORS:20130410-102006664
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:37852
Deposited By: Tony Diaz
Deposited On:12 Aug 2013 22:31
Last Modified:03 Oct 2019 04:51

Repository Staff Only: item control page