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DNA-Mediated Signaling

Barton, Jacqueline K. (2013) DNA-Mediated Signaling. Biophysical Journal, 104 (2). 2A. ISSN 0006-3495. doi:10.1016/j.bpj.2012.11.031.

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Many experiments have now shown that double helical DNA can serve as a conduit for efficient charge transport over long distances. We have seen, for example, that oxidative damage to DNA can be promoted from a distance as a DNA-mediated redox process. Photophysical, electrochemical and biochemical experiments have been conducted to characterize this chemistry. Uniquely, this chemistry is exquisitely sensitive to perturbations in the DNA base stack, such as arise with base mismatches, lesions, and protein binding. We have explored how this chemistry may be used within the cell for long range signaling. Studies are described where DNA charge transport is utilized in signaling DNA-bound proteins, both to regulate transcription and to activate repair of base lesions under conditions of oxidative stress. DNA charge transport chemistry provides an opportunity to carry out redox chemistry at a distance.

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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2013 Biophysical Society. Published by Elsevier Inc.
Issue or Number:2
Record Number:CaltechAUTHORS:20130425-131548699
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Official Citation:Jacqueline K. Barton, DNA-Mediated Signaling, Biophysical Journal, Volume 104, Issue 2, Supplement 1, 29 January 2013, Page 2a, ISSN 0006-3495, 10.1016/j.bpj.2012.11.031.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:38118
Deposited By: Tony Diaz
Deposited On:01 May 2013 23:34
Last Modified:09 Nov 2021 23:33

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