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Category-dependent and category-independent goal-value codes in human ventromedial prefrontal cortex

McNamee, Daniel and Rangel, Antonio and O'Doherty, John P. (2013) Category-dependent and category-independent goal-value codes in human ventromedial prefrontal cortex. Nature Neuroscience, 16 (4). pp. 479-485. ISSN 1097-6256. PMCID PMC3665508. doi:10.1038/nn.3337. https://resolver.caltech.edu/CaltechAUTHORS:20130429-092028603

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Abstract

To choose between manifestly distinct options, it is suggested that the brain assigns values to goals using a common currency. Although previous studies have reported activity in ventromedial prefrontal cortex (vmPFC) correlating with the value of different goal stimuli, it remains unclear whether such goal-value representations are independent of the associated stimulus categorization, as required by a common currency. Using multivoxel pattern analyses on functional magnetic resonance imaging (fMRI) data, we found a region of medial prefrontal cortex to contain a distributed goal-value code that is independent of stimulus category. More ventrally in the vmPFC, we found spatially distinct areas of the medial orbitofrontal cortex to contain unique category-dependent distributed value codes for food and consumer items. These results implicate the medial prefrontal cortex in the implementation of a common currency and suggest a ventral versus dorsal topographical organization of value signals in the vmPFC.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nn.3337DOIArticle
http://rdcu.be/cnJnPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665508PubMed CentralArticle
ORCID:
AuthorORCID
O'Doherty, John P.0000-0003-0016-3531
Additional Information:© 2013 Nature Publishing Group. Received 03 December 2012. Accepted 24 January 2013. Published online 17 February 2013. We thank V. Chib and E. Boorman for helpful discussions, and J. Stanley for assistance. This work was funded by Science Foundation Ireland grant 08/IN.1/B1844 and a grant from the Gordon and Betty foundation (to J.P.O.). Author Contributions: D.M., A.R. and J.P.O. designed the experiment. D.M. acquired and analyzed the data. D.M., A.R. and J.P.O. wrote the manuscript. J.P.O. supervised the project. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
Science Foundation, Ireland08/IN.1/B1844
Gordon and Betty Moore FoundationUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC3665508
DOI:10.1038/nn.3337
Record Number:CaltechAUTHORS:20130429-092028603
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130429-092028603
Official Citation:Category-dependent and category-independent goal-value codes in human ventromedial prefrontal cortex - pp479 - 485 Daniel McNamee, Antonio Rangel & John P O'Doherty doi:10.1038/nn.3337
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:38148
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:29 Apr 2013 16:36
Last Modified:09 Nov 2021 23:33

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