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The path for metal complexes to a DNA target

Komor, Alexis C. and Barton, Jacqueline K. (2013) The path for metal complexes to a DNA target. Chemical Communications, 49 (35). pp. 3617-3630. ISSN 1359-7345. PMCID PMC3660861. doi:10.1039/c3cc00177f.

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The discovery of cisplatin as a therapeutic agent stimulated a new era in the application of transition metal complexes for therapeutic design. Here we describe recent results on a variety of transition metal complexes targeted to DNA to illustrate many of the issues involved in new therapeutic design. We describe first structural studies of complexes bound covalently and non-covalently to DNA to identify potential lesions within the cell. We then review the biological fates of these complexes, illustrating the key elements in obtaining potent activity, the importance of uptake and subcellular localization of the complexes, as well as the techniques used to delineate these characteristics. Genomic DNA provides a challenging but valuable target for new transition metal-based therapeutics.

Item Type:Article
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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2013 The Royal Society of Chemistry. Received 8th January 2013, Accepted 8th February 2013. First published online 20 Feb 2013. We are grateful to the NIH (GM33309) for their support of this research.
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Issue or Number:35
PubMed Central ID:PMC3660861
Record Number:CaltechAUTHORS:20130503-130417175
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:38265
Deposited By: Tony Diaz
Deposited On:03 May 2013 21:38
Last Modified:09 Nov 2021 23:36

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