Taylor, Anne Marion and Wu, Jason and Tai, Hwan-Ching and Schuman, Erin M. (2013) Axonal Translation of β-Catenin Regulates Synaptic Vesicle Dynamics. Journal of Neuroscience, 33 (13). pp. 5584-5589. ISSN 0270-6474. PMCID PMC3651888. doi:10.1523/JNEUROSCI.2944-12.2013. https://resolver.caltech.edu/CaltechAUTHORS:20130507-102304932
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Abstract
Many presynaptic transcripts have been observed in axons, yet their role in synapse development remains unknown. Using visually and pharmacologically isolated presynaptic terminals from dissociated rat hippocampal neurons, we found that ribosomes and β-catenin mRNA preferentially localize to recently formed boutons. Locally translated β-catenin accumulates at presynaptic terminals, where it regulates synaptic vesicle release dynamics. Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata.
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| Additional Information: | © 2013 the authors. Received June 21, 2012. Revision received January 14, 2013. Accepted February 7, 2013. Author contributions: A.M.T. designed research; A.M.T., J.W., and H.-C.T. performed research; A.M.T. analyzed data; A.M.T. and E.M.S. wrote the paper. We thank Nicole Calakos (Duke University), Dan Albaugh (University of North Carolina) and Richard Weinberg (University of North Carolina) for helpful discussions and comments on the manuscript. We thank Naomi McArthur (California Institute of Technology) and Graham Mulvany (University of North Carolina) for participation in data analysis. A.M.T. acknowledges support from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (K12HD073945) and the Simons Foundation (SFARI #236390 to A.M.T.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. A.M.T. is a cofounder of Xona Microfluidics. | ||||||||||||
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| Issue or Number: | 13 | ||||||||||||
| PubMed Central ID: | PMC3651888 | ||||||||||||
| DOI: | 10.1523/JNEUROSCI.2944-12.2013 | ||||||||||||
| Record Number: | CaltechAUTHORS:20130507-102304932 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20130507-102304932 | ||||||||||||
| Official Citation: | Anne Marion Taylor, Jason Wu, Hwan-Ching Tai, and Erin M. Schuman Axonal Translation of β-Catenin Regulates Synaptic Vesicle Dynamics The Journal of Neuroscience, 27 March 2013, 33(13):5584-5589; doi:10.1523/JNEUROSCI.2944-12.2013 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 38316 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Ruth Sustaita | ||||||||||||
| Deposited On: | 07 May 2013 17:47 | ||||||||||||
| Last Modified: | 09 Nov 2021 23:36 |
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