A Caltech Library Service

Axonal Translation of β-Catenin Regulates Synaptic Vesicle Dynamics

Taylor, Anne Marion and Wu, Jason and Tai, Hwan-Ching and Schuman, Erin M. (2013) Axonal Translation of β-Catenin Regulates Synaptic Vesicle Dynamics. Journal of Neuroscience, 33 (13). pp. 5584-5589. ISSN 0270-6474. PMCID PMC3651888. doi:10.1523/JNEUROSCI.2944-12.2013.

PDF - Published Version
Creative Commons Attribution Non-commercial Share Alike.


Use this Persistent URL to link to this item:


Many presynaptic transcripts have been observed in axons, yet their role in synapse development remains unknown. Using visually and pharmacologically isolated presynaptic terminals from dissociated rat hippocampal neurons, we found that ribosomes and β-catenin mRNA preferentially localize to recently formed boutons. Locally translated β-catenin accumulates at presynaptic terminals, where it regulates synaptic vesicle release dynamics. Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Schuman, Erin M.0000-0002-7053-1005
Additional Information:© 2013 the authors. Received June 21, 2012. Revision received January 14, 2013. Accepted February 7, 2013. Author contributions: A.M.T. designed research; A.M.T., J.W., and H.-C.T. performed research; A.M.T. analyzed data; A.M.T. and E.M.S. wrote the paper. We thank Nicole Calakos (Duke University), Dan Albaugh (University of North Carolina) and Richard Weinberg (University of North Carolina) for helpful discussions and comments on the manuscript. We thank Naomi McArthur (California Institute of Technology) and Graham Mulvany (University of North Carolina) for participation in data analysis. A.M.T. acknowledges support from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (K12HD073945) and the Simons Foundation (SFARI #236390 to A.M.T.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. A.M.T. is a cofounder of Xona Microfluidics.
Funding AgencyGrant Number
Simons Foundation236390
Issue or Number:13
PubMed Central ID:PMC3651888
Record Number:CaltechAUTHORS:20130507-102304932
Persistent URL:
Official Citation: Anne Marion Taylor, Jason Wu, Hwan-Ching Tai, and Erin M. Schuman Axonal Translation of β-Catenin Regulates Synaptic Vesicle Dynamics The Journal of Neuroscience, 27 March 2013, 33(13):5584-5589; doi:10.1523/JNEUROSCI.2944-12.2013
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:38316
Deposited By: Ruth Sustaita
Deposited On:07 May 2013 17:47
Last Modified:09 Nov 2021 23:36

Repository Staff Only: item control page