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Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia

Yu, Rongjun and Hsieh, Ming H. and Wang, Hsiao-Lan Sharon and Liu, Chih-Min and Liu, Chen-Chung and Hwang, Tzung-Jeng and Chien, Yi-Ling and Hwu, Hai-Gwo and Tseng, Wen-Yih Isaac (2013) Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia. PLoS ONE, 8 (3). Art. No. e57516. ISSN 1932-6203. PMCID PMC3590274. doi:10.1371/journal.pone.0057516. https://resolver.caltech.edu/CaltechAUTHORS:20130509-154207759

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Abstract

Low frequency oscillations are essential in cognitive function impairment in schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific frequency bands. Here, we used a regional homogeneity (ReHo) method combined with resting-state functional magnetic resonance imaging to investigate low frequency spontaneous neural activity in the three different frequency bands (slow-5:0.01–0.027 Hz; slow-4:0.027–0.08 Hz; and typical band: 0.01–0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. Compared with controls, schizophrenia patients exhibited decreased ReHo in the precentral gyrus, middle occipital gyrus, and posterior insula, whereas increased ReHo in the medial prefrontal cortex and anterior insula. Significant differences in ReHo between the two bands were found in fusiform gyrus and superior frontal gyrus (slow-4> slow-5), and in basal ganglia, parahippocampus, and dorsal middle prefrontal gyrus (slow-5> slow-4). Importantly, we identified significant interaction between frequency bands and groups in the inferior occipital gyrus and caudate body. This study demonstrates that ReHo changes in schizophrenia are widespread and frequency dependent.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pone.0057516DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590274/PubMed CentralArticle
ORCID:
AuthorORCID
Yu, Rongjun0000-0003-0123-1524
Additional Information:© 2013 Yu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. August 8, 2012; Accepted: January 23, 2013; Published: March 6, 2013. This study was supported in part by the National Health Research Institute, Taiwan (NHRI-EX101-10145NI), National Science Council, Taiwan (NSC100-3112-B-002-016), and National Taiwan University (97HM00273). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank all the participants and their families for their participation in our study. Author Contributions: Conceived and designed the experiments: MHH HGH WYIT. Performed the experiments: MHH CML CCL TJH YLC. Analyzed the data: RY HLSW. Contributed reagents/materials/analysis tools: HGH WYIT. Wrote the paper: RY MHH HLSW.
Funders:
Funding AgencyGrant Number
National Health Research Institute (Taipei)NHRI-EX101-10145NI
National Science Council (Taipei)NSC100-3112-B-002-016
National Taiwan University97HM00273
Issue or Number:3
PubMed Central ID:PMC3590274
DOI:10.1371/journal.pone.0057516
Record Number:CaltechAUTHORS:20130509-154207759
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130509-154207759
Official Citation:Yu R, Hsieh MH, Wang H-LS, Liu C-M, Liu C-C, et al. (2013) Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia. PLoS ONE 8(3): e57516. doi:10.1371/journal.pone.0057516
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:38402
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:09 May 2013 23:11
Last Modified:09 Nov 2021 23:37

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