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Directional interactions and cooperativity between mechanosensitive membrane proteins

Haselwandter, Christoph A. and Phillips, Rob (2013) Directional interactions and cooperativity between mechanosensitive membrane proteins. Europhysics Letters, 101 (6). Art. No. 68002 . ISSN 0295-5075. PMCID PMC4193682. doi:10.1209/0295-5075/101/68002. https://resolver.caltech.edu/CaltechAUTHORS:20130523-084817493

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Abstract

While modern structural biology has provided us with a rich and diverse picture of membrane proteins, the biological function of membrane proteins is often influenced by the mechanical properties of the surrounding lipid bilayer. Here we explore the relation between the shape of membrane proteins and the cooperative function of membrane proteins induced by membrane-mediated elastic interactions. For the experimental model system of mechanosensitive ion channels we find that the sign and strength of elastic interactions depend on the protein shape, yielding distinct cooperative gating curves for distinct protein orientations. Our approach predicts how directional elastic interactions affect the molecular structure, organization, and biological function of proteins in crowded membranes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1209/0295-5075/101/68002DOIArticle
http://iopscience.iop.org/0295-5075/101/6/68002/PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193682PubMed CentralArticle
http://arxiv.org/abs/1209.3083arXivDiscussion Paper
ORCID:
AuthorORCID
Phillips, Rob0000-0003-3082-2809
Additional Information:© 2013 EPLA. Received 18 January 2013; accepted 25 February 2013; published online 26 March 2013. This work was supported at USC by the National Science Foundation through NSF award number DMR-1206332 and at Caltech by a Collaborative Innovation Award of the Howard Hughes Medical Institute, and the National Institutes of Health through NIH award number R01 GM084211 and the Director’s Pioneer Award. We thank C. L. Henley, W. S. Klug, M. Lindén, D. C. Rees, and N. S. Wingreen for helpful comments.
Funders:
Funding AgencyGrant Number
NSFDMR-1206332
Howard Hughes Medical Institute (HHMI) Collaborative Innovation AwardUNSPECIFIED
NIHR01 GM084211
NIH Director’s Pioneer AwardUNSPECIFIED
Issue or Number:6
Classification Code:PACS: 34.20.-b; 87.16.D-; 87.15.kt
PubMed Central ID:PMC4193682
DOI:10.1209/0295-5075/101/68002
Record Number:CaltechAUTHORS:20130523-084817493
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130523-084817493
Official Citation:Directional interactions and cooperativity between mechanosensitive membrane proteins Christoph A. Haselwandter and Rob Phillips 2013 EPL 101 68002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:38651
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Jun 2013 23:18
Last Modified:09 Nov 2021 23:38

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