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Optical phase conjugation (OPC)-assisted isotropic focusing

Jang, Mooseok and Sentenac, Anne and Yang, Changhuei (2013) Optical phase conjugation (OPC)-assisted isotropic focusing. Optics Express, 21 (7). pp. 8781-8792. ISSN 1094-4087. PMCID PMC3641024.

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Isotropic optical focusing – the focusing of light with axial confinement that matches its lateral confinement, is important for a broad range of applications. Conventionally, such focusing is achieved by overlapping the focused beams from a pair of opposite-facing microscope objective lenses. However the exacting requirements for the alignment of the objective lenses and the method’s relative intolerance to sample turbidity have significantly limited its utility. In this paper, we present an optical phase conjugation (OPC)-assisted isotropic focusing method that can address both challenges. We exploit the time-reversal nature of OPC playback to naturally guarantee the overlap of the two focused beams even when the objective lenses are significantly misaligned (up to 140 microns transversely and 80 microns axially demonstrated). The scattering correction capability of OPC also enabled us to accomplish isotropic focusing through thick scattering samples (demonstrated with samples of ~7 scattering mean free paths). This method can potentially improve 4Pi microscopy and 3D microstructure patterning.

Item Type:Article
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URLURL TypeDescription CentralArticle
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2013 Optical Society of America. Received 26 Feb 2013; revised 22 Mar 2013; accepted 23 Mar 2013; published 2 Apr 2013. We acknowledge Dr. Meng Cui and Dr. Colin Shepherd for initial discussions. We thank Dr. Benjamin Judkewitz, Ms. Ying Min Wang and Mr. Roarke Horstmeyer for helpful discussions and help with the experiments. This work is supported by NIH 1DP2OD007307-01, R21 EB012255 and GIST-Caltech Collaborative Research Fund. Dr. Anne Sentenac is additionally funded by Region Provence Alpes Cote d'azur, APEX 2011.
Funding AgencyGrant Number
NIHR21 EB012255
GIST-Caltech Collaborative Research FundUNSPECIFIED
Region Provence Alpes Cote d'azurAPEX 2011
Issue or Number:7
Classification Code:OCIS codes: (070.5040) Phase conjugation; (090.1995) Digital holography; (090.2880) Holographic interferometry; (110.7050) Turbid media; (220.1000) Aberration compensation; (220.1080) Active or adaptive optics.
PubMed Central ID:PMC3641024
Record Number:CaltechAUTHORS:20130524-100820411
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Official Citation:Jang, M., A. Sentenac, et al. (2013). "Optical phase conjugation (OPC)-assisted isotropic focusing." Opt. Express 21(7): 8781-8792.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:38664
Deposited By: Tony Diaz
Deposited On:31 May 2013 19:09
Last Modified:09 Mar 2020 13:19

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