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SpCoel1: a sea urchin profilin gene expressed specifically in coelomocytes in response to injury

Smith, L. Courtney and Britten, Roy J. and Davidson, Eric H. (1992) SpCoel1: a sea urchin profilin gene expressed specifically in coelomocytes in response to injury. Molecular Biology of the Cell, 3 (4). pp. 403-414. ISSN 1059-1524. PMCID PMC275591.

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SpCoel1 is a single copy gene that is specifically expressed in most of the coelomocytes of the adult purple sea urchin, Strongylocentrotus purpuratus. The 4-kb transcript from this gene has a relatively short (426 nucleotide) open reading frame (ORF) with long 3' and 5' untranslated regions. The ORF encodes a protein that has strong amino acid sequence similarity to profilins from yeast to mammals. Transcript titrations of SpCoel1 show significant increases per coelomocyte in animals that have been physiologically challenged. Increases in transcript levels are of similar magnitudes between animals receiving different treatments, such as injuries from needle punctures or from injections of foreign cells. The evidence presented here implies a molecular mechanism by which this lower deuterostome defense system responds to external insult, viz that an external "injury signal" activates a signal transduction system, which in turn mediates the alterations in cytoskeletal state that are required for coelomocyte activation.

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Additional Information:Copyright © 1992 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,. the appearance of) the edited manuscript in an online issue of MBoC, the nonexclusive right to copy, distribute, or display the manuscript subject to the terms of the Creative Commons–Noncommercial–Share Alike 3.0 Unported license ( Submitted December 20, 1991; Accepted January 29, 1992 We thank Patrick Leahy, Golda Bernstein, Debra Jackson, and Marcia Goodstein for technical assistance. We acknowledge E. Rothenberg, B. Hough-Evans, and two reviewers for helpful comments on the manuscript. L.C.S. was supported by a Developmental Biology grant to E.H.D. from the Lucille P. Markey Charitable Trust and by NIH Grant HD-05753 to E.H.D.
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Lucille P. Markey Charitable TrustUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC275591
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ID Code:3902
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Deposited On:18 Jul 2006
Last Modified:02 Oct 2019 23:07

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