Brunelli, N. A. and Neidholdt, E. L. and Giapis, K. P. and Flagan, R. C. and Beauchamp, J. L. (2013) Continuous Flow Ion Mobility Separation with Mass Spectrometric Detection Using a Nano-Radial Differential Mobility Analyzer at Low Flow Rates. Analytical Chemistry, 85 (9). pp. 4335-4341. ISSN 0003-2700. doi:10.1021/ac3032417. https://resolver.caltech.edu/CaltechAUTHORS:20130702-110722087
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Abstract
We describe a hybrid mass-mobility instrument in which a continuous-flow ion mobility classifier is used as a front-end separation device for mass spectrometric analysis of ions generated with an electrospray ionization source. Using nitrogen as a carrier gas, the resolving power of the nano-radial differential mobility analyzer (nRDMA) for nanometer-sized ions is 5–7 for tetraalkylammonium ions. Data are presented demonstrating the ability of the system to resolve the different aggregation and charge states of tetraalkylammonium ions and protonated peptides using a quadrupole ion trap (QIT) mass spectrometer to analyze the mobility-classified ions. Specifically, data are presented for the two charge states of the decapeptide Gramicidin S. A key feature of the new instrument is the ability to continuously transmit ions with specific mobilities to the mass spectrometer for manipulation and analysis.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2013 American Chemical Society. Received: November 7, 2012; Accepted: April 2, 2013; Published: April 2, 2013. The authors declare no competing financial interest. | |||||||||
| Issue or Number: | 9 | |||||||||
| DOI: | 10.1021/ac3032417 | |||||||||
| Record Number: | CaltechAUTHORS:20130702-110722087 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20130702-110722087 | |||||||||
| Official Citation: | Continuous Flow Ion Mobility Separation with Mass Spectrometric Detection Using a Nano-Radial Differential Mobility Analyzer at Low Flow Rates N. A. Brunelli, E. L. Neidholdt, K. P. Giapis, R. C. Flagan, and J. L. Beauchamp Analytical Chemistry 2013 85 (9), 4335-4341 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 39184 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 03 Jul 2013 18:14 | |||||||||
| Last Modified: | 09 Nov 2021 23:43 |
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