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Cooperative Binding

Stefan, Melanie I. and Le Novère, Nicolas (2013) Cooperative Binding. PLoS Computational Biology, 9 (6). e1003106. ISSN 1553-734X. PMCID PMC3699289. doi:10.1371/journal.pcbi.1003106. https://resolver.caltech.edu/CaltechAUTHORS:20130703-114250348

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Abstract

Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand’s concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pcbi.1003106DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699289/PubMed CentralArticle
ORCID:
AuthorORCID
Le Novère, Nicolas0000-0002-6309-7327
Additional Information:© 2013 Stefan, Le Novère. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published June 27, 2013. Editor: Shoshana Wodak, University of Toronto, Canada. Funding: The authors received no specific funding for this article. Competing Interests: The authors have declared that no competing interests exist. The version history of the text file and the peer reviews (and response to reviews) are available as supporting information in Text S1 and S2.
Issue or Number:6
PubMed Central ID:PMC3699289
DOI:10.1371/journal.pcbi.1003106
Record Number:CaltechAUTHORS:20130703-114250348
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130703-114250348
Official Citation:Stefan MI, Le Nove`re N (2013) Cooperative Binding. PLoS Comput Biol 9(6): e1003106. doi:10.1371/journal.pcbi.1003106
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39222
Collection:CaltechAUTHORS
Deposited By: Melanie Stefan
Deposited On:03 Jul 2013 20:05
Last Modified:09 Nov 2021 23:43

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