A Caltech Library Service

Mechanism of carbon isotope fractionation associated with lipid synthesis

DeNiro, Michael J. and Epstein, Samuel (1977) Mechanism of carbon isotope fractionation associated with lipid synthesis. Science, 197 (4300). pp. 261-263. ISSN 0036-8075. doi:10.1126/science.327543.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


The low carbon-13/carbon-12 ratio of lipids is shown to result from isotopic fractionation during the oxidation of pyruvate to acetyl coenzyme A. In vitro analysis of the kinetic isotope effects of this reaction indicates that there will be a large, temperature-dependent difference in the carbon-13/carbon-12 ratio between the methyl and carbonyl carbon atoms of acetyl coenzyme A and between those carbon atoms of lipid components which derive from them.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Additional Information:© 1977 American Association for the Advancement of Science. Received 10 January 1977; revised 14 March 1977. Supported by NSF grant DES71-00558 A03. This is contribution No. 2854, Division of Geological and Planetary Sciences, California Institute of Technology
Funding AgencyGrant Number
NSFDES71-00558 A03
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Caltech Division of Geological and Planetary Sciences2854
Issue or Number:4300
Record Number:CaltechAUTHORS:20130703-132744091
Persistent URL:
Official Citation:Mechanism of carbon isotope fractionation associated with lipid synthesis MJ DeNiro and S Epstein Science 15 July 1977: 197 (4300), 261-263. [DOI:10.1126/science.327543]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39227
Deposited By: Tony Diaz
Deposited On:09 Jul 2013 18:27
Last Modified:09 Nov 2021 23:43

Repository Staff Only: item control page