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Evidence for dynamic rearrangements but lack of fate or position

McKinney, Mary Cathleen and Fukatsu, Kazumi and Morrison, Jason and McLennan, Rebecca and Bronner, Marianne E. and Kulesa, Paul M. (2013) Evidence for dynamic rearrangements but lack of fate or position. FASEB Journal, 27 . Art. No. 965.1. ISSN 0892-6638.

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Neural crest cells emerge from the dorsal trunk neural tube and migrate ventrally to colonize neuronal derivatives, as well as dorsolaterally to form melanocytes. Here, we test whether different dorsoventral levels in the neural tube have similar or differential ability to contribute to neural crest cells and their derivatives. To this end, we precisely labeled neural tube precursors at specific dorsoventral levels of the chick neural tube using fluorescent dyes and a photoconvertible fluorescent protein. Neural tube and neural crest cell dynamics were then examined in vivo and in slice culture using 2-photon and confocal time-lapse imaging. The results show that neural crest precursors undergo dynamic rearrangements within the neuroepithelium, yielding an overall ventral to dorsal movement toward the midline of the neural tube, where they exit in a stochastic manner to populate multiple derivatives. No differences were noted in the ability of precursors from different dorsoventral levels of the neural tube to contribute to neural crest derivatives, with the exception of sympathetic ganglia, which appeared to be "filled" by the first population to emigrate. Rather than restricted developmental potential, however, this is likely due to a matter of timing.

Item Type:Article
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Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2013 FASEB. Grant Funding Source: NIH grant 1RO1HD057922.
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Record Number:CaltechAUTHORS:20130711-105030561
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39318
Deposited By: Tony Diaz
Deposited On:11 Jul 2013 18:05
Last Modified:03 Oct 2019 05:06

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