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Chip-scale fluorescence microscope based on a silo-filter complementary metal-oxide semiconductor image sensor

Lee, Seung Ah and Ou, Xiaoze and Lee, J. Eugene and Yang, Changhuei (2013) Chip-scale fluorescence microscope based on a silo-filter complementary metal-oxide semiconductor image sensor. Optics Letters, 38 (11). pp. 1817-1819. ISSN 0146-9592. PMCID PMC3740726. https://resolver.caltech.edu/CaltechAUTHORS:20130715-100248148

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Abstract

We demonstrate a silo-filter (SF) complementary metal-oxide semiconductor (CMOS) image sensor for a chip-scale fluorescence microscope. The extruded pixel design with metal walls between neighboring pixels guides fluorescence emission through the thick absorptive filter to the photodiode of a pixel. Our prototype device achieves 13 μm resolution over a wide field of view (4.8  mm × 4.4  mm). We demonstrate bright-field and fluorescence longitudinal imaging of living cells in a compact, low-cost configuration.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OL.38.001817 DOIArticle
http://www.opticsinfobase.org/ol/abstract.cfm?uri=ol-38-11-1817PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740726/PubMed CentralArticle
ORCID:
AuthorORCID
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2013 Optical Society of America. Received March 13, 2013; accepted April 8, 2013; posted April 16, 2013 (Doc. ID 186601); published May 21, 2013. This project is funded by the NIH under grant 1R01AI096226-01.
Funders:
Funding AgencyGrant Number
NIH1R01AI096226-01
Issue or Number:11
Classification Code:OCIS codes: (110.0180) Microscopy; (180.2520) Fluorescence microscopy
PubMed Central ID:PMC3740726
Record Number:CaltechAUTHORS:20130715-100248148
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20130715-100248148
Official Citation:Optics Letters, Vol. 38, Issue 11, pp. 1817-1819 (2013) http://dx.doi.org/10.1364/OL.38.001817
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39358
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Jul 2013 21:49
Last Modified:09 Mar 2020 13:19

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