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Luminescent probes for DNA base mismatches

McConnell, Anna J. and Barton, Jacqueline (2013) Luminescent probes for DNA base mismatches. In: 245th ACS National Meeting & Exposition, Abstracts of Papers, April 7-11, 2013, New Orleans, LA.

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Mismatch repair deficiency has been implicated in a no. of diseases, such as cancer, and DNA base mismatches accumulate when mismatch repair pathways are defective. The metal complex [Rh(bpy)2(chrysi)]3+ has been shown to be selective for DNA base mismatches due to the sterically expansive chrysi ligand, and there is interest in developing a luminescent analog for diagnosing mismatch repair deficiencies. The complex [Ru(bpy)2(dppz)]2+ is a light switch for DNA and shows enhanced luminescence in the presence of DNA defects. In an effort to improve the luminescence response for mismatched over matched DNA, a new family of ruthenium(II) complexes has been prepd. with sterically expansive ligands and their luminescence responses to DNA defects have been investigated.

Item Type:Conference or Workshop Item (Paper)
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McConnell, Anna J.0000-0001-7329-4319
Barton, Jacqueline0000-0001-9883-1600
Additional Information:© 2013 American Chemical Society.
Record Number:CaltechAUTHORS:20130716-132849585
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:39395
Deposited By: Tony Diaz
Deposited On:12 Aug 2013 22:49
Last Modified:03 Oct 2019 05:06

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