McConnell, Anna J. and Barton, Jacqueline (2013) Luminescent probes for DNA base mismatches. In: 245th ACS National Meeting & Exposition, Abstracts of Papers, April 7-11, 2013, New Orleans, LA. https://resolver.caltech.edu/CaltechAUTHORS:20130716-132849585
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Abstract
Mismatch repair deficiency has been implicated in a no. of diseases, such as cancer, and DNA base mismatches accumulate when mismatch repair pathways are defective. The metal complex [Rh(bpy)2(chrysi)]3+ has been shown to be selective for DNA base mismatches due to the sterically expansive chrysi ligand, and there is interest in developing a luminescent analog for diagnosing mismatch repair deficiencies. The complex [Ru(bpy)2(dppz)]2+ is a light switch for DNA and shows enhanced luminescence in the presence of DNA defects. In an effort to improve the luminescence response for mismatched over matched DNA, a new family of ruthenium(II) complexes has been prepd. with sterically expansive ligands and their luminescence responses to DNA defects have been investigated.
| Item Type: | Conference or Workshop Item (Paper) | ||||||
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| Additional Information: | © 2013 American Chemical Society. | ||||||
| Record Number: | CaltechAUTHORS:20130716-132849585 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20130716-132849585 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 39395 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 12 Aug 2013 22:49 | ||||||
| Last Modified: | 03 Oct 2019 05:06 |
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